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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-37: Genetic Association Study of FOXP3 Gene Polymorphisms in Allergic Rhinitis and Serum Immunoglobulin Levels
چکیده انگلیسی مقاله Objective: Allergic rhinitis is a common chronic inflammatory disease of nasal airways. That is characterized by Th2-deviated immune response. The FOXP3 gene encodes a transcription factor thought to be essential for the development and function of regulatory T (Treg) cells, which are play a key role in balancing immune responses to maintain peripheral tolerance against antigens, including autoantigens and foreign allergens. However, information about FOXP3 gene in Allergic rhinitis is limited. The aim of present study was to analyze the association between FOXP3 gene polymorphisms with susceptibility to allergic rhinitis and Serum IgE & IgA Levels in Iranian population. Materials and Methods: 122 allergic rhinitis patients and 130 allergy-free controls were recruited according to age and gender. We investigated two FOXP3 promoter single nucleotide polymorphisms (SNPs), -3279 A>C and -924 G>A, by using PCR sequencespecific primer (PCR-SSP) technique. Serum total IgE was measured by Enzyme-linked immunosorbent assay (ELISA) and Serum total IgA was measured by using Neflometry system. Statistical analysis was conducted with SPSS16.0 software. Results: We found that increased risk of allergic rhinitis was associated with the FOXP3 -3279 AC genotype (odds ratio 2.73, 95% confidence interval 1.59-7.21; p=0.001) and there was no evidence of an increased risk associated with the FOXP3-924 A/G genotype. The serum IgE and IgA level in the subgroup with TIM-1 gene polymorphisms was no significantly different from the sobgroup without these SNPs (p> 0.05). Conclusion: Our results suggest that the FOXP3 polymorphisms appear to contribute to the risk of allergic rhinitis. Also has provided genetic data on FOXP3 gene in Iranian population and a basis for searching immunemediated disease-related FOXP3haplotype.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1569
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