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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-44: Aberrant Methylation of Integrin α4 and E-cadherin Using Laser Capture Microdisections
چکیده انگلیسی مقاله Objective: Prostate cancer is the second most common malignancy in men worldwide. Aberrant epigenetic events such as DNA hypermethylation and altered histone acetylating have been observed in prostate cancer, in which they affect a large number of genes. Adhesion molecules are responsible for the maintenance of the epithelial phenotype. Cadherins and integrins are major adhesion molecules regulating cell-cell and cell-matrix interactions. Studies have reported the correlation between adhesion molecule expression and prostate carcinoma. Integrins are cell-surface receptors that mediate adhesion to the extracellular matrix (ECM) and cell-cell interactions. Integrins are involved in many pathological conditions such as inflammation and tumor progression. Role of integrins in tumor growth and metastasis is obvious. Screening of aberrant epigenetic events such as DNA hypermethylation is needed to identify prostate cancer related genes. Our aim is to study the expression profiles of integrin α4 and E-cadherin in our patient population. Materials and Methods: Laser capture microdissection microscopy was used to obtain tissue sections for DNA extraction. Tissue samples microdissected were subjected to Methylation-specific PCR (MSP) to evaluate the promoter methylation statues of E-cadherin and α4 integrin genes in 30 prostate cancer and 40 benign prostate hyperplasia (BPH) patients. Results: Integrin α4 and E-cadherin was hypermethylated in 66.6% and 6.6% of cases, respectively and none were observed in BPH samples. Conclusion: High levels of Integrin α4 methylation in microdissected tumor samples may lead to serious effect of integrin α4 in human prostate cancer
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1576
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