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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-51: Zinc Deficiency in β-Thalassemia Majorthe Impact of Antioxidant Therapy
چکیده انگلیسی مقاله Objective: Zinc deficiency is thought to be one of the major pathogenetic mechanisms of immune abnormalities in β-thalassemia. This study was performed to determine the possible relationship between immunological defects and zinc deficiency in Iranian patients with β-thalassemia major. Materials and Methods: Regarding antioxidant and iron chelating activities of silymarin, a flavonolignan complex isolated from Silybum marianum, a 3-month randomized double-blind clinical trial was conducted in 70 β-thalassemia major patients in order to investigate the beneficial effect of silymarin to restore zinc deficiency in β-thalassemia major patients under conventional iron chelation therapy by desferrioxamine. Patients were randomized to receive a silymarin (Legalon®, 140 mg) tablet 3 times a day plus conventional desferrioxamine therapy. The second group received the same therapy but a placebo tablet instead of silymarin. Plasma samples were deproteinized by trichloroacetic acid and the levels of zinc were measured using colorimetric kit. Results: Results indicated decreased plasma zinc levels in thalassemia patients compared to controls. However, plasma and 24 hours urinary zinc levels showed no significant change in β-thalassemia patients who were treated by silymarin compared to placebo. Conclusion: This study showed that combination therapy of silymarin with desferrioxamine could not recover urinary zinc excretion caused by desferrioxamine therapy in β-thalassemia major.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1583
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