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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-57: Anti-Angiogenic Effects of Thalidomide in Patients with Metastatic Renal Cell Carcinoma
چکیده انگلیسی مقاله Objective: Even with advent of expansive biologic therapies in the treatment of metastatic renal cell carcinoma (mRCC), the progression free survival (PFS) and overall survival (OS) rates are still not very promising. Thalidomide, initially marketed as a sedative drug in 1950s, is now known to have anti-angiogenic potential by inhibiting the VEGF and fibroblast growth factor (FGF). We aimed to evaluate the role of thalidomide in our patients with mRCC and the efficacy, toxicity and response rates to this drug. Materials and Methods: Between November 2008 and April 2009, 80 patients with mRCC who had either progressed on or were not suitable for immunotherapy/biologic therapy; received thalidomide at dose 400mg daily after their informed consent. Thalidomide was continued until the time of disease progression or documented severe toxicity. Primary endpoints were the safety, response, PFS and OS rates using SPSS version 16.0. Results: Median follow-up was 18 months (15-20). Median age was 51.11 years (range 23-73). Male population was predominant (73.8%). The bone (47.5%), lungs (32.5%) and lymph nodes (10%) were frequent sites of distant metastases. Forty percent had previous different systemic treatments. Grade 3 and 4 toxicities were; fatigue (42.5%), sensory neuropathy (10%), deep venous thrombosis (8.8%) and gastrointestinal upset (7.5%). Response rates were as; partial (60%), stable disease (15%), progression (18.8%) and 6.2% were not evaluated. Median PFS and OS rates were 7 months and 19 months respectively. Conclusion: Low dose thalidomide resulted in manageable toxicity, better response rates, PFS and OS in our patients with mRCC. Further large randomized trials are warranted.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1589
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