این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P-71: Circulating Basic Fibroblast Growth Factor in Serum of Gastric Ulcers Patients as a Biomarker of Wound Severity
چکیده انگلیسی مقاله Objective: Basic fibroblast growth factor (bFGF) is a glycoprotein with stimulating ability of angiogenesis. In addition, bFGF play an important role in wound healing process in some tissue for example gastrointestinal tract, but its ability for discrimination of various stages of wound severity in these diseases didn’t report. Therefore we aimed to determine the bFGF levels in gastric ulcers patients compared with healthy control as a biomarker for staging the severity of wound. Materials and Methods: The study group consisted of 33 patients with gastric ulcer and 27 healthy controls. The diagnosis of patients was based on standard clinical, endoscopic, and histological criteria’s. Serum levels of bFGF were analyzed by an ELISA kit. Results: There were no statistical differences between mean age in patients (52.5 ± 18.7 vs. 47.0 ± 16.0 years old) compared with control (p< 0.05). According to the histological findings, 19 (57.6%) patients were in moderate stage of ulcer and 14(42.4%) patients were in the sever stage of gastric ulcer. Mean bFGF serum levels in patients group (7.8 ± 1.3pg/ml) were lower than the healthy group in crude data, but in statistical analysis the differences was not significant (8.2 ± 1.4pg/ml, p=0.082). Mean bFGF serum levels in patients with severe stage of gastric ulcer were greater than patients in moderate gastric ulcer (8.4 ± 1.3 vs. 7.4 ± 1.2pg) and the differences was statistically significant (p< 0.05). Conclusion: Differences in serum bFGF levels in patients with severe stage of gastric ulcer vs. moderate gastric ulcer was significant. Therefore serum bFGF levels measurements could be used as a useful clinical tool for discrimination of patients with severe stage of gastric ulcer vs. moderate gastric ulcer, when endoscopic and a histological examination is not possible to perform
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله
نشانی اینترنتی http://celljournal.org/journal/article/abstract/1602
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات