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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی P-74: Comparison of Serum C3 and C3a, C3d Levels in Systemic Lupus Erythematosus Patients During Active Disease and after Remission
چکیده انگلیسی مقاله Objective: SLE is an autoimmune disease with various clinical and serologic manifestations. In SLE flair serum levels of complements decrease and their fragments increase, that may be more reliable reflection of disease activity. The present study was performed to compare serum level c3 and its fragments level in SLE flair facing stable state. Materials and Methods: Type of study was analytical pre-post. Sampling procedure was census as blood sample of all active SLE patients diagnosed according to ACR classification criteria was taken and repeated after treatment in stable state. Patients with infectious disease were excluded. Serum C3 level has been measured by SRID, C3a and C3d by Elisa. Statistical analysis was performed with SPSS 16, Wilcoxon signed ranks test, and p< 0.05 was significant. Results: Twelve out of 20 patients experienced stable state in one year so eight patients were omitted in this report. Mean of serum C3 level was 54.5 ± 17.7 mg% in flair and 99.8 ± 35.7 mg% in remission, the increasing level was significant (p=0.004). Mean of serum C3a level was 724.4 ± 254.3 ng/ml in flair and 690.3 ± 196.3 ng/ml in remission, the decreasing level was not significant (p=0.754). Mean serum C3d level was 12.1 ± 8.38 micgreq/ml in flair and 9.6 ± 8.77 micgreq/ml in remission, and the decreasing level was not significant (p=0.239). Conclusion: Our study indicates that in SLE flair serum C3 level decreases and after treatment significantly increases but its degradation products (C3a, C3d) increase in flair and decrease after treatment but the decreasing level is not significant. It may be due to low number of our patients or may indicate late onset normalization of complement fragments. This needs more investigations.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1605
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