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International Journal of Fertility and Sterility، جلد ۱۱، شماره ۲، صفحات ۱۰۵-۱۱۱
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عنوان انگلیسی Evaluation of relationship between BMI with vitamin D receptor gene expression and vitamin D levels of follicular fluid in overweight patients with polycystic ovary syndrome
چکیده انگلیسی مقاله Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder. The roles of vitamin D in the regulation of metabolic modulations specifically involving insulin action and reproduction processing are introduced. In addition, obesity appears to be closely associated with severity of PCOS. The aim of this study was to evaluate the effect of BMI on vitamin D levels in follicular fluid and vitamin D receptor (VDR) expression levels in granulosa cells. Materials and methods: This prospective case-control cross-sectional study was conducted on 80 women with average ages of 20-35 years referred for in-vitro fertilization. Patients were divided into four groups and serum levels of testosterone and insulin resistance (HOMA-IR) were evaluated at the puncture time; also vitamin D levels of follicular fluid were evaluated. VDR gene expression was assayed by quantified-PCR technique. Results: Vitamin D levels of follicular fluid decreased in PCOS patients compared with non-PCOS. Also over-weight individuals had lower vitamin D levels compared with normal- weight patients. Vitamin D levels of follicular fluid were highly correlated with BMI (r = - 0.51, P < 0.001). HOMA-IR values were significantly higher in women of PCOS/Overweight and PCOS/Normal weight than in women of non-PCOS/Normal weight (p < 0.001). The gene expression data of VDR in granulosa cells were significantly lower in the PCOS/Overweight group compared with the non-PCOS/Normal weight (P < 0.001). Conclusion: Our findings indicate that there are significant differences in the VDR gene expression in granulosa cells and vitamin D of follicular fluid in PCOS/overweight patients.
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نویسندگان مقاله عصمت آقاداود | esmat aghadavod


حکیمه عین | hakimeh mollae


محمد نوری | mohammad nouri


حامد همیشه کار | hamed hamishehkar


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4704
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-367899.pdf
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