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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی I-26: Dynamic Analysis of Type 2 Diabetic Progression with Proteomic Approach
چکیده انگلیسی مقاله Type 2 diabetes is a typical chronic disease that needs many years for progressing, and a typical systemsdeficiency that involves metabolic dysfunctions of many different tissues of the body. Understanding the molecular properties of diabetic progression at systemslevel is a big challenge in the systems-biology era. We reason that blood plasma proteome is an ideal “window” for observing global and dynamic progression of type 2 diabetes, since the circulation system is basic “highways” of the body for transporting all kinds of metabolic related molecules and, importantly, the plasma proteome is considered as the most comprehensive and largest version consisting of many different proteins that are secreted, or shed, or leaked from cells and tissues throughout the body. Here we present a dynamic analysis of diabetic rat- plasma proteome from prediabetic stage to diabetic stage by combining mass spectrometric and mathematical techniques. Based on computing analysis of 553 overlapped plasma proteins between diabetic rat, Goto-Kakizaki (GK) rat, and nondiabetic rat, Wistar rat, we first time demonstrate that GK rats preserved a larger entropic values than Wistar rats at systems-level throughout time. Furthermore, using our newly developed computing approach, we characterize 14 featured plasma proteins either significantly overrepresented or underrepresented all the time as well 112 dynamic plasma proteins significantly differentiated from time to time during the diabetic progression.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1508
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