این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی O-1: Sicilian δβ-Thalassemia Is the Most Common Deletion in the Anemic Patients from the North of Iran
چکیده انگلیسی مقاله Objective: Hereditary persistence of fetal hemoglobin (HPFH) and δβ-thalassemia are heterogenous disorders characterized by elevated levels of fetal hemoglobin (Hb F). The aim of this study was to perform a molecular characterization of patients with HPFH and δβ -thalassemia phenotype in the north of Iran. Materials and Methods: DNA samples belonging to thirty patients with mild microcytic hypochromic anemia and high level of Hb F were tested for common deletions reported in beta globin gene cluster using Gap- PCR technique. Results: Our results show that Sicilian δβ- thalassemia and Asian-lndian inversion-deletion γδβ-thalssemia and hemoglobin Hb Lepore are respectively the most abundant common mutations in the north of Iran. This is the first time that molecular characterization of such number of delta beta thalassemia from the north of Iran is reported. Conclusion: This study emphasize that molecular characterization of δβ-thalassemia is important in at risk couples presenting microcytic anemia and should be considered in premarital screening and prenatal diagnosis centers for a more efficient thalassemia major prevention program. We also suggest the inclusion of HbF measurement in premarital screening tests for any hemoglobinopathies prevention program in north of Iran.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله
نشانی اینترنتی http://celljournal.org/journal/article/abstract/1509
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات