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Cell Journal، جلد ۱۳، شماره Supplement، صفحات ۰-۰
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عنوان انگلیسی O-19: Above DNA: Predicting Epigenetic Signature Hypoxic Response
چکیده انگلیسی مقاله Hypoxia response system is a tissue-specific Oxygensensing system, which regulates the synthesis of a transcription factor known as hypoxia inducible factor 1 (HIF 1). This transcription factor controls the expression of many important genes that have impacts on both development and hypoxia related diseases. Body response in hypoxic states such as altitude change or work performance has been different. Data suggest that 10% of the mountaineers seem to react to hypoxia with an exaggerated increase of pulmonary circulation pressure. It can be argued that substantial inter-individual variability in the adaptive response to hypoxia could represent non-physiological factors as well as insensitivity of physiological markers to hypoxia-induced adaptation. These findings may be also attributed to the fact that environmental cues like hypoxia can trigger gene expression. This presentation addresses the normo-baric hypoxic state in an environmental and occupational setting and its effect on cellular and organ level. This study postulates that epigenetic signatures may represent an additional mechanism to promote and maintain a hypoxicadapted cellular phenotype. In other word, normo-baric hypoxic states might induce stable changes in phenotype, perhaps through epigenetic modifications.
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نشانی اینترنتی http://celljournal.org/journal/article/abstract/1527
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