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International Journal of Fertility and Sterility، جلد ۱۰، شماره ۲، صفحات ۲۳۹-۲۴۴
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عنوان انگلیسی Effect of Withania somnifera (L.) Dunal on Sex Hormone and Gonadotropin Levels in Addicted Male Rats
چکیده انگلیسی مقاله Objective: Opioid consumption has been widely increasing across the globe; however, it can cause adverse effects on the body. Morphine, an opioid, can reduce sex hormones and fertility. Withania somnifera (WS) is a traditional herb used to improve sexual activities. This study strives to investigate the effect of WS on sex hormones and gonadotropins in addicted male rats. Materials and methods: In this experimental study, forty-eight male National Maritime Research Institute (NMRI) rats were randomly divided into four groups: i. Control group, ii. WS-treated control group, iii. Addicted group, and iv. WS-treated addicted group. Water- soluble morphine was given to rats for 21 days to induce addiction, concurrently the treated groups (2 and 4) also received WS plant-mixed pelleted food (6.25%). At the end of the treatment, the sex hormone and gonadotropin levels of the rats’ sera were determined in all the groups. Results: Except for follicle-stimulating hormone (FSH), morphine reduced most of the gonadotropin and sex hormone levels. Whereas WS caused a considerable increase in the hormones in the treated addicted group, there was only a slight increase in the treated control group. Conclusion: WS increased sex hormones and gonadotropins-especially testosterone, estrogen, and luteinizing hormone-in the addicted male rats and even increased the progesterone level, a stimulant of most sex hormones in addicted male rats.
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نویسندگان مقاله بتول رحمتی | batool rahmati


محمد حسن قوسیان مقدم | mohammad hassan ghosian moghaddam


محسن خلیلی | mohsen khalili


احسان عنایتی | ehsan enayati


مریم ملکی | maryam maleki


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4915
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-368002.pdf
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