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International Journal of Fertility and Sterility، جلد ۱۰، شماره ۱، صفحات ۸۷-۹۳
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عنوان انگلیسی The Effects of Testosterone on Oxidative Stress Markers in Mice with Spinal Cord Injuries
چکیده انگلیسی مقاله Objective: Spinal cord injury (SCI) causes infertility in male patients through erectile dysfunction, ejaculatory dysfunction, semen and hormone abnormalities. Oxidative stress (OS) is involved in poor semen quality and subsequent infertility in males with SCI. The aim of this study is to examine the effects of SCI on the level of testosterone hormone. Materials and methods: In this experimental study, we evaluated the effects of exogenous testosterone on the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as the levels of malondialdehyde (MDA) and protein carbonylation (PCO), as markers of OS, in 10 groups of SCI mice. Total antioxidant capacity (TAC) was determined using the 2,29-azinobis-(3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) radical cation assay. Results: Exogenous testosterone administration in mice with SCI significantly reduced SOD and GPx enzyme activities and MDA level. There was no significant decrease in PCO content. In addition, TAC remarkably increased in the sham and SCI groups not treated with testosterone but remained unchanged in all other experimental groups. Exogenous testosterone also reduced serum testosterone levels in all groups except the positive control group. Conclusion: Our cumulative data indicated that SCI could cause sterility by disturbing the plasmatic testosterone balance. The normal level of endogenous testosterone was not completely restored by exogenous testosterone administration.
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نویسندگان مقاله حمید چوبینه | hamid choobineh


محمد علی صدیقی گیلانی | mohammad ali sadighi gilani


پروین پاسالار | parvin pasalar


عیسی جهانزاد | issa jahanzad


رستم قربانی | rostam ghorbani


غلامرضا حسن زاده | gholamreza hassanzadeh


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4773
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-368047.pdf
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زبان مقاله منتشر شده en
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