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International Journal of Fertility and Sterility، جلد ۱۰، شماره ۱، صفحات ۱۲۰-۱۲۶
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عنوان انگلیسی A Preliminary Study: N-acetyl-L-cysteine Improves Semen Quality following Varicocelectomy
چکیده انگلیسی مقاله Objective: Surgery is considered the primary treatment for male infertility from clinical varicocele. One of the main events associated with varicocele is excessive production of reactive oxygen species (ROS). N-acetyl-L-cysteine (NAC), an antioxidant that scavenges free radicals, is considered a supplement to alleviate glutathione (GSH) depletion during oxidative stress. Despite beneficial effects of NAC in other pathological events, there is no report on the effect of NAC in individuals with varicocele. Therefore, the aim of this study is to evaluate the outcome of NAC on semen quality, protamine content, DNA damage, oxidative stress and fertility following varicocelectomy. Materials and methods: This prospective clinical trial included 35 infertile men with varicocele randomly divided into control (n=20) and NAC (n=15) groups. We assessed semen parameters, protamine content [chromomycin A3 (CMA3)], DNA integrity [terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL)] and oxidative stress [2', 7'-dichlorodihydrofluorescein-diacetate (DCFH-DA)] before and three months after varicocelectomy. Results: Percentage of abnormal semen parameters, protamine deficiency, DNA fragmentation and oxidative stress were significantly decreased in both groups compared to before surgery. We calculated the percentage of improvement in these parameters compared to before surgery for each group, then compared the results between the groups. Only percentage of protamine deficiency and DNA fragmentation significantly differed between the NAC and control groups. Conclusion: The results of this study, for the first time, revealed that NAC improved chromatin integrity and pregnancy rate when administered as adjunct therapy post-varicocelectomy (Registeration Number: IRCT201508177223N5).
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نویسندگان مقاله فروغ برکت | foroogh barekat


مرضیه تولایی | marziyeh tavalaee


محمدرضا دیمه | mohammad reza deemeh


مهسا بحرینیان | mahsa bahreinian


لیلا آزادی | leila azadi


همایون عباسی | homayoun abbasi


شهلا روزبهانی | shahla rozbahani


محمد حسین نصر اصفهانی | mohammad hossein nasr esfahani


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4777
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-368056.pdf
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