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International Journal of Fertility and Sterility، جلد ۹، شماره ۳، صفحات ۲۷۷-۲۸۴
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عنوان انگلیسی In Vitro Fertilization, Levels of Pro-Inflammatory Factors and Lipid Peroxidation
چکیده انگلیسی مقاله Background: Infertility is a problem concerning 10-15% of the individuals in the fertile period. This study investigated effects of proinflammatory factors as well as lipid hydroperoxides (LPO) levels upon in vitro fertilization (IVF) success. Materials and methods: In this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (group-1), 26 infertile women before (group-2) and after (group-3) IVF treatment were analyzed. Leptin, leptin receptor, resistin, tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) were analyzed using enzyme-linked immunosorbent assay (ELISA). LPO was determined spectrophotometrically. Mann- Whitney U test, paired samples t test, Wilcoxon signed-rank test as well as Pearson correlation analysis by SPSS were performed for statistical analysis. Results: TNF-α, resistin and LPO levels increased (P=0.020, P=0.003, P=0.001, respectively) in group-3 compared to group-2. A significant increase in LPO was noted both in group-2 and -3 compared to controls (P=0.000). LPO were higher in non-pregnants than pregnants in group-2. For pregnants, significant correlations were observed between leptin and resistin in group-2 and TNF-α and leptin in group-3. None of these correlations were found for the women, who could not conceive. Conclusion: LPO, leptin-resistin correlation, associations with TNF-α may be helpful during the interpretation of IVF success rates.
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نویسندگان مقاله ferdag yildizfer | ferdag yildizfer


orkide donma | orkide donma


مصطفی yen | mustafa yen


ozlem ekmekci | ozlem ekmekci


zubeyde اصلی l karatas ku | zubeyde asli l karatas ku


zafer keser | zafer keser


آحمت esat imal | ahmet esat imal


emin cagil | emin cagil


مرات mengi | murat mengi


حاکان ekmekci | hakan ekmekci


سزای sahmay | sezai sahmay


burcin nalbantoglu | burcin nalbantoglu


مصطفی metin donma | mustafa metin donma


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4541
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-368139.pdf
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