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International Journal of Fertility and Sterility، جلد ۹، شماره ۲.۵، صفحات ۵۷-۵۸
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عنوان انگلیسی P-34: Crocin Ameliorate The In Vitro Fertilization (IVF) in Mice Treated with Cyclophosphamide
چکیده انگلیسی مقاله Background: Oxidative stress induced by cyclophosphamide (CP), as a chemotherapeutic agent, causes vulnerability of sperm and declining the fertility capacity. Then in this study the effect of crocin (saffron extract) on amelioration of these side effects was investigated. Materials and methods: In this study 24 mice were divided in three groups (n=8). Control group received normal saline (0.2 ml/day, IP), CP group received cyclophosphamide (15 mg/kg/week, IP), and CP+Cr group received crocin (200 mg/ kg/day, IP) along with CP for 35 days.Then, the animals were euthanized for obtaining sperm from the tail of epididymis. After stimulation of ovulation in 72 female adult mice, oocytes were collected and transferred in HTF medium that contained BSA. Then, in vitro fertilization (IVF) was done with capacitated sperms. The rate of fertilization and primitive embryonic growth were evaluated for 120 hours. Results: The results showed increase in fertilization, two cell embryos and blastocysts in CP+Cr Group in comparisonto those of CP group (P< 0.05). Also, the crocin in CP+Cr group prevented the increaseof total number of arrested embryos and percentage of arrested embryos type I, II, and III (P< 0.05). Conclusion: This study showed the efficiency of crocin in amelioration of fertility and growth ofprimitive embryo in animals that received CP.
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نویسندگان مقاله z بختیاری | z bakhtiary


r شهروز | r shahrooz


a احمدی | a ahmadi


f سلطانعلی نژاد | f soltanalinejad


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4386
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