این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Fertility and Sterility، جلد ۹، شماره ۲.۵، صفحات ۹۰-۹۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P-112: PGS-Array-CGH Technique: New Technical Approach to Promotion ART Outcome
چکیده انگلیسی مقاله Background: Chromosomal abnormalities are common in embryos from assisted reproductive technology, ranging from 60% abnormal embryos in women < 35 to 80% in women ≥41 years. The majority of numerical chromosome abnormalities detected in cleavage-stage embryos are not compatible with implantation or birth, and their high frequency is likely to have a substantial effect on the success of assisted reproductive treatments. Materials and methods: Preimplantation Genetic Screening (PGS) aims to provide a means of identifying potentially viable euploid embryos, which may have higher chances of producing a pregnancy, to be prioritized for transfer. Prior PGS strategies using Fuorescence In Situ Hybridization (FISH) have involved the analysis of 5, 9, or 12 chromosomes. Nowadays the new generation of PGS methods, 24-chromosome tests, such as CGH, array CGH or single nucleotide polymorphism arrays, are demonstrated to help increase successful outcome rate of ART especially in repeated implantation failure’s cases. The combined use of array CGH and single blastocyst transfer can provide an efficient tool for improving IVF clinical outcomes without increasing the number of transferred embryos and the risk of unwished multiple pregnancies. Results: In view of these, Array-CGH is proved to be highly robust and specific when applied to rapid (24-hour) analysis of single cells biopsied from cleavage-stage embryos. This tool does not require prior testing of parental DNA and thus advance planning and careful scheduling are unnecessary and with respect to the review of the literature, array-CGH will detect approximately 42% more abnormalities and 13% more abnormal embryos than the standard 12-probe FISH approach. Conclusion: In a wider perspective, this technique can also be used in patients who, independent of a RIF’s history, wish to limit the number of transferred embryos to a single one for different personal, social or economic reasons.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله s بینافر | s binaafar


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4467
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات