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International Journal of Fertility and Sterility، جلد ۹، شماره ۱، صفحات ۴۷-۵۴
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عنوان انگلیسی Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran
چکیده انگلیسی مقاله Background: Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously. Materials and methods: In this retrospective study, the pattern of chromosomal aberrations was evaluated during a six-year period from 2005 to 2011. The population under study was 728 couples who attended genetic counseling services for their RSAs at Pardis Clinical and Genetics Laboratory, Mashhad, Iran. Results: In this study, about 11.7% of couples were carriers of chromosomal aberrations. The majority of abnormalities were found in couples with history of abortion, without stillbirth or livebirth. Balanced reciprocal translocations, Robertsonian translocations, inversions and sex chromosome aneuploidy were seen in these cases. Balanced reciprocal translocations were the most frequent chromosomal anomalies (62.7%) detected in current study. Conclusion: These findings suggest that chromosomal abnormalities can be one of the important causes of RSAs. In addition, cytogenetic study of families who experienced RSAs may prevent unnecessary treatment if RSA are caused by chromosomal abnormalities. The results of cytogenetic studies of RSA cases will provide a standard protocol for the genetic counselors in order to follow up and to help these families.
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نویسندگان مقاله سعیده قضایی | saeedeh ghazaey


فاطمه keify | fatemeh keify


فرزانه میرزایی | farzaneh mirzaei


معصومه ملکی | masumeh maleki


سمیرامیس طوطیان | semiramis tootian


میترا احدیان | mitra ahadian


محمدرضا عباس زادگان | mohammad reza abbaszadegan


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4208
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-368720.pdf
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زبان مقاله منتشر شده en
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