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International Journal of Fertility and Sterility، جلد ۹، شماره ۱، صفحات ۷۱-۸۱
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عنوان انگلیسی Effect of Human Umbilical Cord Mesenchymal Stem Cells Transplantation on Nerve Fibers of A Rat Model of Endometriosis
چکیده انگلیسی مقاله Background: Endometriosis is a common, benign, oestrogen-dependent, chronic gynaecological disorder associated with pelvic pain and infertility. Some researchers have identified nerve fibers in endometriotic lesions in women with endometriosis. Mesenchymal stem cells (MSCs) have attracted interest for their possible use for both cell and gene therapies because of their capacity for self-renewal and multipotentiality of differentiation. We investigated how human umbilical cord-MSCs (hUC-MSCs) could affect nerve fibers density in endometriosis. Materials and methods: In this experimental study, hUC-MSCs were isolated from fresh human umbilical cord, characterized by flow cytometry, and then transplanted into surgically induced endometriosis in a rat model. Ectopic endometrial implants were collected four weeks later. The specimens were sectioned and stained immunohistochemically with antibodies against neurofilament (NF), nerve growth factor (NGF), NGF receptor p75 (NGFRp75), tyrosine kinase receptor-A (Trk-A), calcitonin gene-related peptide (CGRP) and substance P (SP) to compare the presence of different types of nerve fibers between the treatment group with the transplantation of hUC-MSCs and the control group without the transplantation of hUC-MSCs. Results: There were significantly less nerve fibers stained with specific markers we used in the treatment group than in the control group (p< 0.05). Conclusion: MSC from human umbilical cord reduced nerve fiber density in the treatment group with the transplantation of hUC-MSCs.
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نویسندگان مقاله یان chen | yan chen


دانک li | dong li


zhe زانگ | zhe zhang


natsuko takushige | natsuko takushige


bei hua kong | bei hua kong


گیو yun ونگ | guo yun wang


نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4211
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/72/article-72-368726.pdf
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زبان مقاله منتشر شده en
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