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International Journal of Fertility and Sterility، جلد ۸، شماره ۲.۵، صفحات ۸-۸
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عنوان انگلیسی I-20: Towards The Transparent Embryo: Dynamics and Ethics of Comprehensive Preimplantation Genetic Screening
چکیده انگلیسی مقاله Background: To study the ethical aspects of comprehensive preimplantation genetic screening (PGS) through microarrays and whole genome sequencing Materials and Methods: In order to pinpoint ethical issues regarding comprehensive embryo screening we have first investigated the technical and moral issues by organizing a campus meeting with experts and by a literature study. Subsequently we have investigated the opinions of professionals regarding the possible introduction of comprehensive screening techniques in the IVF clinic and the ethical implications in a focus group study. We have also investigated the feasibility and analytical and clinical validity and clinical utility of whole genome sequencing for embryo selection. Finally, based on our previous conclusions, we have performed a theoretical reflection on professional responsibility regarding the use of micro-arrays in order to perform comprehensive chromosome screening. Results: The increasing complexity and amount of information yielded by comprehensive testing techniques will lead to challenges to the principle of reproductive autonomy and the right of the child to an open future. Furthermore, it may complicate the responsibility of the clinician regarding the welfare of the future child, and may lead to conflicts with prospective parents. Moreover, the analytic and clinical validity and the clinical utility of whole genome sequencing as a tool for embryo selection is unproven. An alternative testing approach is preconception carrier screening for a number of disorders, combined with targeted PGD for couples at high risk. This may avoid some of the ethical problems of comprehensive embryo screening. Obviously, the ethics of this alternative needs further ethical scrutiny as well. Moreover, there is a need for studies querying the opinions of infertile couples undergoing IVF/PGS regarding the desirability of embryo screening beyond aneuploidy. Conclusion: The introduction of comprehensive screening techniques for embryo selection is premature at best and calls for further ethical reflection that is grounded in empirical work.
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نشانی اینترنتی http://ijfs.ir/journal/article/abstract/3805
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