این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۴، شماره ۲، صفحات ۶۷-۶۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Demonstratin Acidic Mucin Production In Non-Goblet Metaplastic Columnar Cells Of Lower esophagus As an Early Sign Of Barrett Esphonagus In Patient With Gastroesophageal Reflux Diesase
چکیده انگلیسی مقاله Introduction: The aim of this study was to demonstrate changes in nature of mucin and production of acidic forms using PAS-Alcian blue stain at PH=2.5. Appearance of non-goblet metaplastic columnar cells of lower esophagus is considered as an early sign of Barrette sophagus, simultaneous in conjunction or before the appearance of goblet cells in patients with gastroesophageal reflux disease. Material and Methods: Forty four biopsy samples where taken from the squamo-columnar junction of patients with reflux associated columnar metaplasia of lower esophagus who referred to Shariati Hospital during 1378. All specimens were stained by Alcian blue-PAS at PH=2.5 to search for acidic mucin production in non-goblet metaplastic columnar cells of lower esophagus. Colonic mucosa specimen and the goblet cells from 9 cases with overt intestinal metaplasia were used as external and internal positive controls and cardiac type columnar cells were considered as negative control for acidic mucin production. Result: Eight out of 44 biopsy samples taken at squamo-columnar junction of patients with reflux associated columnar metaplasia in lower esophagus showed acidic mucin production in non-goblet metaplastic columnar cells. Conclusion: Alcian blue-PAS stain at PH=2.5 can demonstrate changes in nature of mucin content and reveals acidic mucin production in non-goblet metaplastic columnar cells of lower esophagus in some patients with gastroesophagea appearance of goblet cells and can help in early detection of this premalignant lesion and as a result, better surveillance and follow up of the affected patients.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله
نشانی اینترنتی http://celljournal.org/journal/article/abstract/3645
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/16/article-16-368914.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات