این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Fertility and Sterility، جلد ۸، شماره ۲.۵، صفحات ۷۴-۷۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P-57: Simvastatin Abates Doxorubicin-Induced Teratozoospermia
چکیده انگلیسی مقاله Background: Therapeutic utilities of doxorubicin (DOX), an anticancer anthracycline antibiotic, are limited by its serious dosedependent toxicity to non-target tissues such as testis. The aim of the present study was to elucidate the potential of simvastatin (SIM), a lipid lowering agent with antioxidant and anti-inflammatory activities, to attenuate DOX-induced spermatotoxicity in male mice. Materials and Methods: Male mice, five weeks old, were randomly divided into four groups of six mice each. DOX was administered to two groups of mice in 5 equal intraperitoneal injections over a period of 4 weeks (accumulated dose of 20 mg/kg). One of these groups received 5 equal oral doses of SIM (accumulated dose of 60 mg/kg)along with DOX. A vehicle-treated control group and a SIM control group were also included. Teratozoospermia index (TZI) was defined as the number of abnormalities present per abnormal spermatozoon. Results: A statistically significant elevation of TZI value was observed in the DOX-treated mice as compared to control mice. In contrast, SIM co-administration provided marked normalization in the TZI value when compared to the DOX-only treated group. Conclusion: These findings have indicated that SIM exerts protective effects against DOX-induced spermatogenic disorders. Mechanisms may involve suppressing inflammation and reducing oxidative stress induced by DOX treatment.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله
نشانی اینترنتی http://ijfs.ir/journal/article/abstract/3919
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات