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International Journal of Fertility and Sterility، جلد ۸، شماره ۲.۵، صفحات ۱۹۶-۱۹۶
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عنوان انگلیسی P-185: Hawthorn Berries Ethanolic Extract Lowered Polycystic Ovarian Syndrome- Elevated RNA Damage in Follicular Cells
چکیده انگلیسی مقاله Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder. Various constituents including flavonoids with biological activities including free radical scavenging, anti-lipoperoxidation and anti-inflammatory have been isolated from hawthorn. Due to adverse effect of PCOS on ovarian vascular remodeling as well as PCOS-induced oxidative stress, we aimed to study the hawthorn’s berries hydroalcoholic extract potential effects on estradiol valerate-induced PCOS in rats. Materials and Methods: PCOS was induced in 3 groups of rats (n = 6) by intramuscular injection of estradiol valerate (EV, 4 mg/ratin 0.2 ml sesame oil). The control group only received the vehicle (0.2 ml sesame oil). A 60-day interval was chosen to let the cysts become established. Following the interval time, effects of hawthorn berries extract (HBE, 100 mg/kg, orally) and oral contraceptive pills (OCP, containing 60 μg/kg estradiol, orally) on PCO-induced RNA damage and Angiogenesis were evaluated. The RNA damage and angiogenesis were evaluated by using Bicki’s method and CD31+ immuno-fluorescent analyses, respectively. Results: Observations demonstrated that HBE significantly (p< 0.05) reduced PCO-induced RNA damage and enhanced the micro and macro vessels distribution per one mm2 of the ovarian tissue. Conclusion: Our data suggest that HBE partly reduce the PCOS-induced damages on the ovary by up-regulating the angiogenesis process and down-regulating the RNA damage.
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نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4049
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