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International Journal of Fertility and Sterility، جلد ۸، شماره ۲.۵، صفحات ۲۰۲-۲۰۲
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عنوان انگلیسی P-191: A Comparison of The Effects of Transdermal Estradiol and Estradiol Valerate on Endometrial Receptivity in Frozen-Thawed Embryo Transfer Cycles: A Randomized Clinical Trial
چکیده انگلیسی مقاله Background: The aim of this prospective randomized clinical trial was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in FET cycles, that is, oral estradiol and 17 β-estradiol transdermal patch. Materials and Methods: A total number of 90 patients were scheduled for FET. In the study group (n=45), 17-B estradiol transdermal patches 100 μg were applied from the second day of the cycle and continued every other day. Then each patch was removed after four days. In the control group (n=45), oral estradiol valerate 6 mg started as the same time above and continued daily. Results: There was a significant difference in estradiol level on the day of progesterone administration and the day of embryo transfer between the two groups (p=0.001 in both), but no significant difference was observed between them in biochemical and clinical pregnancy rates (32.6 vs. 33.3%, p=1, 30.2 vs. 33.3%, p=0.81 respectively). The implantation rate tended to be higher in the study group, but it did not achieve a statistical significance. (20.45 vs. 11.7% respectively, p>0.05). Conclusion: In spite of no significant differences in implantation, biochemical and clinical pregnancy rates between the two groups; we can use estradiol transdermal patches instead of oral estradiol in FET cycles. This is due to the reduced costs, drug dose, and emotional stress as well as the simplicity of the protocol for patient.
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نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4055
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