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International Journal of Fertility and Sterility، جلد ۸، شماره ۲.۵، صفحات ۲۷۲-۲۷۲
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عنوان انگلیسی Inm-6: Molecular Genetic Basis of Infertility
چکیده انگلیسی مقاله Background: Sexual reproduction affords the stands for conserving genetic characteristics and sequentially, genetic inconsistency may influence the capability to imitate. Materials and Methods: Research was conducted by subject in PubMed and other databases. Results: A significant number of genotypes have been related with infertility phenotypes and evaluation of precise genes in humans and model systems illuminate the essence of the polygenic and multi-factorial basis of infertility. Single-gene defects are almost certainly to be found among hypogonadotropic hypogonadism patients caused by defects in the KAL genes or the gonadotrophin-releasing hormone receptor genes. An increased risk of having a premutation of the Fragile X syndrome gene is observed in premature ovarian failure. Complex genetic inheritance may elucidate the variable familial associations in polycystic ovary syndrome and endometriosis, but no definitive genetic pathways are as yet known. With recurrent miscarriage, genetic defects causing thrombophilias are 2-fold more likely. Genetic factors implicated in male infertility evident as chromosomal disorders, mitochondrial DNA (mtDNA) mutations, monogenic disorders, multifactorial disorders and endocrine disorders of genetic origin. Genetic disorders like Klinefelter syndrome and Y chromosome microdeletions are known genetic causes of male infertility Conclusion: Accepting the methods used for genetic diagnosis is becoming a standard obligation for the clinical follow of reproductive medicine.
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نشانی اینترنتی http://ijfs.ir/journal/article/abstract/4125
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