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International Journal of Fertility and Sterility، جلد ۷، شماره ۳، صفحات ۷۴-۷۴
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عنوان انگلیسی P-96: Survey of In Vitro Effect of Noscapine on Nitric Oxide Secretion of Human Endometrial Stromal Cell
چکیده انگلیسی مقاله Background: Noscapine is cough suppressant drug with cell inhibitory effect. It is introduced for anti-cancer treatment. The aim of present study was to determine in vitro noscapine effect on nitric oxide (NO) secretion by human endometrial stromal cells. Materials and Methods: Human endometrial biopsies (n=8) were obtained in sterile condition and were chopped mechanically and digested by enzymatic (collagenase, 2 mg/ml) methods. Stromal cells were harvested after using cell strainer (70 and 100 μm) and centrifugation. The cells were divided into four groups: control, 10, 25, 50 and 100 μM noscapine concentration for three culture periods (24, 48, 72 hours), Nitric oxide secretion were assessed by Geriss assay. Data was analyzed by one way ANOVA and p< 0.05 was considered significant. Results: Difference between NO amount were significant in control, 10, 25, 50 and 100 μM noscapine concentration were 35.14, 33.79, 20.7, 19.69 and 18.75 μM at 24-hour culture period (p=.009), 56.22, 53.54,26.84. 25.03 and 22.35 μM at 48-hour(p=0.01), and 73.99, 63.42, 33.33, 32.77 and 30.6 μM at 72-hour (p=0.037) respectively. Conclusion: Noscapine decreased endometrial stromal cells NO secretion in dose dependant manner.
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نشانی اینترنتی http://ijfs.ir/journal/article/abstract/3557
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