این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Fertility and Sterility، جلد ۷، شماره ۳، صفحات ۹۷-۹۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P-161: Effect of Naloxone on Endometrial Growth
چکیده انگلیسی مقاله Background: There is fine correlation between the infertility and lessening of endometrial thickness. In this study the effects of sedative naloxone, and L-arginine, the precursor of nitric oxide (NO), on endometrial thickness of rat uterus was examined. Materials and Methods: Wistar rats (weighing 200-250 g) in Diestrous phase received intra-peritoneal (i.p.) 1. single L-arginine (50 mg/kg), 2. single naloxone (0.4 mg/ kg) and 3. naloxone (0.4 mg/kg) 30 minutes priorly to the L-arginine (50 mg/kg) during 9 days/ once a day. The control group exclusively received saline (1 ml/kg, i.p.)throughout the treatment period. After completion of the treatments, all rats were coupled with intact males and after observation of vaginal plaques they were isolated and graded 0 of gestation. The females were subsequently passed surgical examination in days 19-20 of gestation. Results: Based on the findings the group that only administered L-arginine, nevertheless of endometrial development, showed low pregnancy and fetal count to control. However, naloxone pre-treatment caused significant raise in the rates. The rate, furthermore, showed an increase in single naloxone group. Conclusion: Endometrial wideness may occur due to angiogenesis and expansion of blood flow in the endometrial wall and by growing of the wall glands and matrix. The L-arginine may produce the NO, a putative increasing factor of blood flow. This factor, however, is not as effective as do in the presence of naloxone. The naloxone can develop the endometrial growth in Wistar rat.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله
نشانی اینترنتی http://ijfs.ir/journal/article/abstract/3622
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات