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International Journal of Travel Medicine and Global Health، جلد ۳، شماره ۳، صفحات ۹۵-۹۷
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عنوان انگلیسی Breast Carcinoma; Human Epidermal Growth Factor Receptor-2 (HER-2) and Grading Correlation
چکیده انگلیسی مقاله Introduction: Overexpression of Human Epidermal Growth factor Receptor-2 (HER-2) is one of the most important prognostic and predictive factors of breast cancer, observed in 25% - 30% of breast carcinoma patients leading to poor prognosis and feasible anti HER-2 antibody drugs. The objective of this study was to evaluate the HER-2 frequency in target population and its correlation with histologic grade as well as tumor pathology, estrogen receptor (ER) and P53 in our patients. Methods: A total of 300 cases (all female) aged 24- 80 year, were randomly selected from patients who were admitted in two of the Tehran University of Medical Sciences affiliated centers (Emam Khomeini Cancer Institute and Shariati hospital) over a 2-year period (2013-2014). Assessment of tumors for HER-2, P53, ER, pathological type and histologic grade was performed. HER-2 over expression defined as three plus (+++) in immunohistochemistry (IHC). Results: The mean age was 49.6±11 years. HER-2 over expression was seen in 34% of the patients. Significant correlations were found between HER-2+, P53+ and high histologic grade and ER (P< 0.05). However, there was no significant correlation between HER-2 and pathologic type of tumors in our study. Conclusion: Co-expression of several poor prognostic biomarkers in breast cancer (HER-2 +, P53 +, ER- , high grade) may predict more aggressive phenotype, worse disease and lower overall survival in these patients.
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نویسندگان مقاله سید عباس mirmalek | seyed abbas
department of surgery, islamic azad university, tehran medical sciences branch, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

فاطمه الهام کانی | fatemeh elham
department of surgery, islamic azad university, tehran medical sciences branch, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

arianeb محرابی |
department of general, visceral, and transplantation surgery, university of heidelberg, heidelberg, germany

مهدی چاوشی نژاد | chavoshi nejad
department of surgery, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

سید علیرضا سلیمی طباطبایی | seyed alireza salimi tabatabaee
students amp;amp; 039; research committee, islamic azad university, tehran medical sciences branch, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

یکتا پارسا |
young researchers and elite club, islamic azad university, tehran medical sciences branch, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

سهیلا یداله دماوندی | yadollah damavandi
young researchers and elite club, islamic azad university, tehran medical sciences branch, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

تینا پارسا |
young researchers and elite club, islamic azad university, tehran medical sciences branch, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

امین aidun |
department of biomedical engineering, amirkabir university of technology, tehran, iran
سازمان اصلی تایید شده: دانشگاه صنعتی امیرکبیر (Amirkabir university of technology)

نشانی اینترنتی http://www.ijtmgh.com/article_33212_52ae3909e547e4b7781940b522fad7b0.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/351/article-351-376506.pdf
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زبان مقاله منتشر شده en
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