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International Journal of Travel Medicine and Global Health، جلد ۳، شماره ۱، صفحات ۱۹-۲۱
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عنوان انگلیسی Can Viral Load Predict Liver Histology in Patients With Chronic Hepatitis B?
چکیده انگلیسی مقاله Introduction: Hepatitis B virus (HBV) infection is a global public health problem. Serum HBV DNA measurement is a non-invasive test that predicts the liver disease progression. The aim of this study was to determine the HBV DNA level and look for a relation between the HBV DNA level and liver histology. Methods: This was a cross sectional study on chronic hepatitis B infected patients in Tehran Hepatitis Center from 2006 to 2010. Percutaneus liver biopsy was performed in all patients. Patients with a history of any treatment and co-infection of HCV, HDV and HIV were excluded. Results: 301 patients were included in this study. The mean age was 34.63±13.25 years. Mean serum HBV DNA level was 1.35* 108 ± 10.5*109 copies/ml. Mean inflammatory score (grade) was 5.54±3.26 and fibrosis (stage) was 1.93±1.56. There wasn’t any significant relation between age and sex with liver histology. No significant relation was seen between liver histology and the HBV DNA level. HBe Ag positive patients had a higher serum HBV DNA level. Conclusion: There wasn’t any significant relation between liver histology and the HBV DNA level. We suggest using liver biopsy as a golden standard. In addition we need more studies in this field.
کلیدواژه‌های انگلیسی مقاله Chronic Hepatitis B, Liver Histology, Serum HBV DNA
نویسندگان مقاله اشرف کرباسی |
baqiyatallah research center of gastroenterology and liver disease, baqiyatallah university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

بهزاد بافنده |
baqiyatallah research center of gastroenterology and liver disease, baqiyatallah university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

سید موید علویان | seyed moayed
baqiyatallah research center of gastroenterology and liver disease, baqiyatallah university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

امین صبوری |
chemical injury research center, baqiyatallah university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

نشانی اینترنتی http://www.ijtmgh.com/article_33162_5a5f97ea76122d9abf6d6a91b2ea508f.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/351/article-351-376528.pdf
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زبان مقاله منتشر شده en
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