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Journal of Injury and Violence Research، جلد ۴، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Safety of Granulocyte-Colony Stimulating Factor (G-CSF) administration for post-rehabilitation spinal cord injury patients: A phase I open-label study
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background and Objective: Spinal cord injury (SCI) is a devastating neurological disorder causing various symptoms depending on the location, extent and degree of the damage. Granulocyte-colony stimulating factor (G-CSF) is a major growth factor in the activation and differentiation of granulocytes. This cytokine has been widely and safely employed clinically in different conditions over many years. On the other hand, the beneficial effects of G-CSF administration in spinal cord injury models have been shown in different studies. Patients and methods: This study was conducted in the Brain and Spinal Injury Research Center and all of its procedures were approved by Tehran University of Medical Sciences Ethics Committee. A total of 11 patients with spinal cord injury were enrolled in the study and subcutaneous administration of GCSF was performed for 5 days in all of them. Follow up period was about 1 year. The American Spinal Injury Association (ASIA) scale used for motor and sensory assessment and the Spinal Cord Independence Measure (SCIM III) was used to evaluate the changes on the ability of performing basic everyday tasks. Results: Based on ASIA neurological examination scale, mean upper extremity motor score changed from 28.36 ± 19.64(Mean ± SD) to 29.91 ± 19.95 and there was no change in lower extremity motor score, light touch and pin prick sensory score had a modest improvement 3.91 and 1.27 scores respectively. However, changes in motor and sensory scores were statistically significant (P Mild side effects of GCSF treatment such as skin rash (1 case) and myalgia were observed. However, serious complications increasing the mortality and morbidity rates were not found. Conclusion: The findings of our study indicate that GCSF administration in the SCI patients appears safe and effective up to 1 year post injection. However, a randomized, placebo-controlled double blinded clinical trial with longer follow up is recommended to further assessed these findings.
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نویسندگان مقاله هوشنگ صابری | hooshang saberi


نازی درخشان راد | nazi derakhshan rad


میرسعید یکانی | mir saeed yekaninezhad


کیوان طیبی میبدی | keyvan tayebi meibodi


حمیده طهماسبی | hamide tahmasebi


نشانی اینترنتی http://jivresearch.org/jivr/index.php/jivr/article/view/373
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Oral Abstracts
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