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Journal of Injury and Violence Research، جلد ۴، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Effects of magnesium sulfate on the clinical course and GCS of patients with a severe diffuse axonal injury
چکیده انگلیسی مقاله Background and Objective: Previous studies have shown that magnesium sulfate (MgSO4) administered in a patient with a diffuse axonal injury (DAI) can serve as a useful neuroprotective agent. The present study was conducted to examine whether magnesium sulfate has a therapeutic efficacy and safety in patients with a severe diffuse axonal injury. Methods: Adult patients admitted within 1 hour of a closed Traumatic Brain Injury (TBI) with a severe diffuse axonal injury that met eligibility criteria were randomly selected and divided into two groups. Our treatment guidelines consisted of an initial loading dose of 50 mg/kg magnesium sulfate and then 50 mg/kg QID (quarter in die) up to 24 hours after the trauma. The outcome measures were mortality, Glasgow Coma Scale (GCS) score, and motor function scores which were assessed up to 2 months post-trauma. Results: Magnesium showed a significant positive effect on GCS score at 2 months post-trauma (P=0.03). Motor functioning scores of patients in the MgSO4 group were higher than those in the control group but this was not statistically significant (P = 0.51). Conclusion: Findings of the present study demonstrated that administration of magnesium sulfate following severe DAI can have neuroprotective effect.
کلیدواژه‌های انگلیسی مقاله Severe diffuse axonal injury, Magnesium sulfate, Outcome
نویسندگان مقاله مسلم شاکری | moslem shakeri


فیروز صالح پور | firooz salehpour


علی احمدوند | ali ahmadvand


رزیتا جعفری | rozita jafari


عبدالرسول صفاییان | abdolrasoul safaiyan


علی مشکینی | ali meshkini


نشانی اینترنتی http://jivresearch.org/jivr/index.php/jivr/article/view/418
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