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Journal of Medical Microbiology and Infectious Diseases، جلد ۳، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Prevalence of IMP and VIM Metallo-Beta-Lactamases in Pseudomonas aeruginosa Isolates from Clinical and Environmental Specimens in Intensive Care Units (ICUs) of Rasht Hospitals, Iran
چکیده انگلیسی مقاله Introduction: Pseudomonas aeruginosa is one of the leading causes of nosocomial infections, and antibiotic resistance of this pathogen is an important concern in treating such infections. The current work was conducted to investigate the prevalence of bla-IMP, and bla-VIM metallo-beta-lactamase (MBL) among clinical and environmental P. aeruginosa isolates obtained from ICUs of different hospitals in Rasht, Iran. Methods: A total number of 35 P. aeruginosa strains including 20 clinical and 15 environmental strains were isolated from ICUs. The isolated bacteria were screened for MBL production using Combined Disc Synergy Testing (CDST) assay. The frequency of bla-IMP and bla-VIM among MBL producing P. aeruginosa (MBL-PA) was investigated using Polymerase Chain Reaction (PCR). Also, the antibiotic susceptibility of all isolates was determined. Results: According to the results, 51% of isolates were regarded as MBL-PA while bla-IMP or bla-VIM genes were detected in 37% of isolates. The environmental isolates showed higher resistance to the majority of antibiotics compared to the clinical isolates, and MBL genes were more prevalent among environmental isolates. Conclusion: Higher resistance of environmental P. aeruginosa strains in ICUs shows a need to pursue newer approaches, including novel cleaning methods and surveillance programs, to reduce nosocomial infections.
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نویسندگان مقاله متین صابری | matin saberi
rasht, iran


حجت اله زمانی | hojjatolah zamani
namjoo street, rasht


علی صالح زاده | ali salehzadeh
rasht, iran
نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-120-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/350/article-350-383310.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Anti-microbial agents, resistance and treatment protocols
نوع مقاله منتشر شده Original article
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