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Iranian Journal of Psychiatry، جلد ۱۲، شماره ۲، صفحات ۱۳۴-۱۴۱
عنوان فارسی
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عنوان انگلیسی Efficacy of N-Acetylcysteine Augmentation on Obsessive Compulsive Disorder: A Multicenter Randomized Double Blind Placebo Controlled Clinical Trial
چکیده انگلیسی مقاله Objective: Glutamate is considered a target for treating obsessive-compulsive disorder (OCD). The efficacy and safety of the nutritional supplement of N-Acetylcysteine (NAC) as an adjuvant to serotonin reuptake inhibitor (SSRI) for treating children and adolescents with OCD has never been examined. Methods: This was a 10-week randomized double-blind placebo-controlled clinical trial with 34 OCD outpatients. The patients received citalopram plus NAC or placebo. Yale-Brown Obsessive-Compulsive Scale (YBOCS) and Pediatric Quality of Life Inventory (PedsQL™) were used. Adverse effects were monitored. Results: YBOCS score was not different between the two groups at baseline, but the score was different between the two groups at the end of this trial (P< 0.02). The YBOCS score of NAC group significantly decreased from 21.0(8.2) to 11.3(5.7) during this study. However, no statistically significant decrease of YBOCS was found in the placebo group. The Cohen’s d effect size was 0.83. The mean change of score of resistance/control to obsessions in the NAC and placebo groups was 1.8(2.3) and 0.8(2.1), respectively (P = 0.2). However, the mean score of change for resistance/control to compulsion in the NAC and placebo groups was 2.3(1.8) and 0.9(2.3), respectively. Cohen’s d effect size was 0.42. The score of three domains of quality of life significantly decreased in N-Acetylcysteine group during this trial. However, no statistically significant decrease was detected in the placebo group. No serious adverse effect was found in the two groups. Conclusion: This trial suggests that NAC adds to the effect of citalopram in improving resistance/control to compulsions in OCD children and adolescents. In addition, it is well tolerated.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله احمد غنی زاده | ahmad ghanizadeh
research center for psychiatry and behavioral sciences, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمدی | mohammad reza mohammadi
psychiatry and psychology research center, roozbeh hospital, tehran university of medical sciences, tehran, iran department of psychiatry, roozbeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شهلا بحرینی | shahla bahraini
. research center for psychiatry and behavioral sciences, shiraz university of medical sciences, shiraz, iran - department of psychiatry, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

زهرا کشاورزی | zahra keshavarzi
psychiatry and psychology research center, roozbeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی فیروزآبادی | ali firoozabadi
research center for psychiatry and behavioral sciences, shiraz university of medical sciences, shiraz, iran - department of psychiatry, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

علی علوی شوشتری | ali alavi shoshtari
research center for psychiatry and behavioral sciences, shiraz university of medical sciences, shiraz, iran - department of psychiatry, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://ijps.tums.ac.ir/index.php/ijps/article/view/1040
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/64/article-64-385542.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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