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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۴-۴
عنوان فارسی O ۴: Kynurenine Impairs MbMEC Function in Vitro Through Arylhydrocarbon Receptor Activation
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عنوان انگلیسی O 4: Kynurenine Impairs MbMEC Function in Vitro Through Arylhydrocarbon Receptor Activation
چکیده انگلیسی مقاله In the development of neuroinflammatory diseases, alterations of the blood brain barrier (BBB) represent key events. The integrity of the BBB is partially maintained by endothelia cells (ECs), since they actively limit the transmigration of immune cells. However, the factors that cause endothelial cells to develop an immune cell-permissive phenotype are poorly understood. In general, it has been shown that vascular dysfunction can be caused by kynurenine pathway (KP) metabolites. In the initial step of the KP, the bioactive intermediate synthesized is kynurenine (Kyn). It is known to activate the arylhydrocarbon receptor (AhR), a ligand binding transcription factor that mediates immune responses. To examine if this pathway has an effect on the BBB, we investigated the effects of Kyn-mediated AhR activation in primary isolated murine brain microvascular endothelial cells (MbMECs) in vitro. First, we confirmed AhR expression in MbMECs at RNA and protein levels. Transendothelial electrical resistance (TEER) of MBMEC monolayers was unaffected by Kyn treatment. However, treatment with Kyn did cause an increased migration of T-cells. Addition of MNF, an AhR specific inhibitor, reversed this effect. These findings were further confirmed by an increase in the intracellular adhesion protein 1 (ICAM-1) expression in KYN-treated MBMECs. These results suggest a role of KYN in MBMEC dysfunction via AHR activation.
کلیدواژه‌های انگلیسی مقاله Brain, Immune cells, Adhesion protein
نویسندگان مقاله lisa epping | lisa epping
universitätsklinik münster, institut für translationale neurologie, münster, germany


tobias ruck | tobias ruck
universitätsklinik münster, institut für translationale neurologie, münster, germany


میکاییل platten | michael platten
universitätsklinik heidelberg, institut für neurologie, münster, germany


کرین loser | karin loser
universitätsklinik münster, klinik für dermatologie, münster, germany


sven meuth | sven meuth
universitätsklinik münster, institut für translationale neurologie, münster, germany
نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-822&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385593.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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