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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۹-۹
عنوان فارسی O ۹: Immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis: A Systematic Review
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عنوان انگلیسی O 9: Immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis: A Systematic Review
چکیده انگلیسی مقاله Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) transplantation. Several studies have been conducted, investigating immunomodulatory effects of neural stem cells (NSCs) in order to assess their efficacy in the animal model of MS, but still controversies have remained. Our study aim was to systematically review the existing papers in the field of immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis. The systematic review was conducted according to the preferred reporting items for systematic reviews guidelines. We searched PubMed and Scopus databases based on the relevant medical subject headings (MeSH) of Immunomodulation, neural stem cell, and multiple sclerosis and all articles before January 2017 were included. The included studies had accurate data for immune mechanisms assessment and almost all reported neurologic clinical score assessment. Totally, 30 articles were eligible to be included in our systematic review out of 233 articles found at initial search. Studies showed exert immune modulation when neural stem cells (NSCs) are transplanted in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). Regarding the potent immunomodulatory effects of neural stem cells (NSCs) and their beneficial effects in experimental autoimmune encephalomyelitis (EAE), including their capacity for neuroprotection and Immunomodulation it seems that NSCs may be a new therapeutic method in MS therapy.
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نویسندگان مقاله ساناز شیخیان | sanaz sheykhian
islamic azad university, mashhad, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

سجاد سحاب نگاه | sajad sahab negah
neuroscience department, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-827&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385598.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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