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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۲۴-۲۴
عنوان فارسی O ۲۴: Functional Role of The K۲p Potassium Channel Task-۳ in A Syngeneic Murine Glioma Model
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی O 24: Functional Role of The K2p Potassium Channel Task-3 in A Syngeneic Murine Glioma Model
چکیده انگلیسی مقاله To investigate the effects of the two-pore-domain potassium (K2P) channel TASK-3 in a syngeneic murine model for malignant glioma. Malignant or high-grade glioma (WHO grade III and IV) are the most common and most aggressive primary brain tumors in adults. Despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. However, recent phase I and II trials have shown promising results for immunotherapies. The potassium-selective K2P ion channel TASK-3 plays a key role in modulating T cell effector functions. TASK-3 has been shown to functionally impact survival in human glioma cells in vivo and in vitro. We used a syngeneic murine glioma model based on the GL261 glioma cell line. Intracranial injection of GL261 cells leads to development of brain tumors in C57BL/6 wildtype and TASK-3-/- mice. On day 29 after tumor cell implantation eight asymptomatic animals (n = 4 C57BL/6 and n = 4 TASK-3-/- mice) were taken for MRI investigation. Symptom-free survival of GL261 tumor-bearing TASK-3-/- mice was significantly longer as compared to C57BL/6 mice (31 days (29-33 days, 95% confidence interval) versus 23 days (20-26 days, 95% confidence interval); Log-rank test P < 0.001). On MRI, tumors of TASK-3-/- mice showed a clear tendency to have smaller volumes as compared to C57BL/6 wildtype mice (5,25 µm³ vs. 15,48 µm³, n.s.). The K2P ion channel TASK-3 plays an important role in local tumor control, as knockout mice exhibit a delayed onset of symptoms and a longer survival after tumor cell implantation. The mechanisms of these effects and the role of other K2P channels are currently under investigation.
کلیدواژه‌های انگلیسی مقاله Glioma, Brain Tumors, Patient
نویسندگان مقاله کریستین توماس | christian thomas
department of neurology, university of münster, münster, germany


توماس müntefering | thomas müntefering
department of neurology, university of münster, münster, germany


ole سیمون | ole simon
department of neurology, university of münster, münster, germany


petra hundehege | petra hundehege
department of neurology, university of münster, münster, germany


tobias ruck | tobias ruck
department of neurology, university of münster, münster, germany


استفان bittner | stefan bittner
department of neurology, university of münster, münster, germany


الیور grauer | oliver grauer
department of neurology, university of münster, münster, germany


sven meuth | sven meuth
department of neurology, university of münster, münster, germany
نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-841&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385612.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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