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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۲۶-۲۶
عنوان فارسی O ۲۶: Treatment of Traumatic Brain Injury in Adult Rats with Injection of Human Epileptic Neural Stem Cells and Nano-Scaffold
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عنوان انگلیسی O 26: Treatment of Traumatic Brain Injury in Adult Rats with Injection of Human Epileptic Neural Stem Cells and Nano-Scaffold
چکیده انگلیسی مقاله Traumatic brain injury (TBI) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of TBI. In the present study, we surveyed the beneficial effects of human adipose-derived stem cells (hADSCs), human epileptic neural stem cells (hENSCs), and PuraMatrix hydrogel (PM) in an acute brain injury model of mild TBI using 3 months rats. hADSCs and hENSCs were transplanted with or without scaffolds into rats brain and the electroencephalography were compared. Modified neurologic severity score (mNSS) tests were performed to measure behavioral outcomes. PM scaffold increased the retention of hENSCs in the lesion site and limited its distribution at the transplanted region. Significantly more hENSCs were detected in the brain when transplanted with PM scaffold. The results showed PM scaffold also efficiently improved cell survival in vivo, resulting in better neural functional recovery. We hypothesized that PM scaffold would improve early engraftment and support the survival of grafted cells and functional recovery post-transplantation.
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نویسندگان مقاله سجاد سحاب نگاه | sajad sahab negah
a. department of neuroscience, mashhad university of medical sciences, mashhad, iran b. shefa neuroscience research center, khatam alanbia hospital, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علی جهانبازی جهان آباد | ali jahanbazi jahan abad
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. department of clinical biochemistry, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

علی گرجی | ali gorji
a. department of neuroscience, mashhad university of medical sciences, mashhad, iran b. shefa neuroscience research center, khatam alanbia hospital, tehran, iran c. epilepsy research center, department of neurology, and department of neurosurgery, westfälische wilhelms-universität münster, münster, germany

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-843&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385614.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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