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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۳۲-۳۲
عنوان فارسی P ۱: Effect of Clavulanic Acid on Trimethyltin-Induced Cytotoxicity in PC۱۲
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عنوان انگلیسی P 1: Effect of Clavulanic Acid on Trimethyltin-Induced Cytotoxicity in PC12
چکیده انگلیسی مقاله Introduction: Trimethyltin (TMT) is a short-chain trialkyltin used as a stabilizer of plastics. It is also a known neurotoxic agent in both human and animals. Clavulanic acid is previously known as a non-competitive inhibitor of β-lactamase. Oral bioavailability, low antibiotic activity and good CNS penetration are important properties of CA which nominated this compound for evaluation neuroprotective effects. Materials and Methods:  PC12 cells were exposed to different concentrations of CA for 24 h. Then, TMT at final concentration 20 µM was added. After 24 h exposure, cell viability was determined using MTT test. For evaluation reactive oxygen species production, 2, 7-dichlorofluorescein diacetate (DCFH-DA) method was used. Additionally the levels of Bax, Bcl-2 and Caspase 3 proteins were evaluated using western blot analysis. Results: Exposure to TMT significantly increased ROS production, Bax/Bcl-2 and Caspase 3 protein levels while decreased cell viability. Pretreatment of cells with CA inhibited ROS production and increased viability. Also, CA could decrease apoptosis through modulation of proteins involved in apoptotic pathway. Conclusion: The oxidative stress and apoptosis pathway have important roles in toxicity of TMT in PC12 cells. Clavulanic acid exhibited protective effects through inhibition of oxidative stress and apoptosis pathway.
کلیدواژه‌های انگلیسی مقاله Clavulanic acid, Trimethyltin, Apoptosis, Oxidative stress
نویسندگان مقاله سمانه سیلاخوری | samane silakhori
pharmaceutical research center, department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حسین حسین زاده | hosein hoseinzadeh
pharmaceutical research center, department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

صغری مهری | soghra mehri
pharmaceutical research center, department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-850&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385620.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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