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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۴۳-۴۳
عنوان فارسی P ۱۲: Study of the Association between Serum Level of Cystatin C and Behavioral Symptoms of ۶-Hydroxydopamine – Induced Parkinsonism in Rat
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی P 12: Study of the Association between Serum Level of Cystatin C and Behavioral Symptoms of 6-Hydroxydopamine – Induced Parkinsonism in Rat
چکیده انگلیسی مقاله Introduction: Parkinson's disease (PD) is the second most neurodegenerative disorder which is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Clinical symptoms do not appear until approximately 70% of dopaminergic neurons and 80% of the striatal dopaminergic terminals have been lost. Thus, detecting nonclinical factors such as detecting biomarker for PD is necessary. In this study, we evaluate the serum level of Cystatin C as a possible biomarker of PD in 6-hydroxydopamine (6-OHDA)-induced Parkinsonism in rat. Materials and Methods:  Rats were divided into two groups: Parkinson and Control. 6-OHDA was administered by stereotaxic surgery into forebrain bundle. Severity of the Parkinsonism was evaluated by Apomorphine (APO)-induced rotational test at the third and sixth week's post-surgery. Also, serum level of Cystatin C was measured before surgery and at the third and sixth weeks post-surgery. Results: Although rats of control group didn't show a significant response to APO, rats of parkinson group showed significant rotations. The rotations at the sixth week's post-surgery were significantly more than the rotations at the third week's post-surgery. However, there was no significant difference between serum level of Cystatin C in rats of control and parkinson group. Also, there was no difference between serum level of Cystatin C in rats of parkinson group before and after the surgery. There was no difference between serum level of Cystatin C and severity of symptoms in rats of parkinson group. Conclusion: Our data show that in 6-OHDA animal model of PD, serum level of Cystatin C cannot predict onset or progress of PD and therefore this compound cannot consider as a biomarker for PD. 
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نویسندگان مقاله علی سربازی golezari | ali sarbazi golezari
a. student research committee, qazvin university of medical sciences, qazvin, iran b. cellular and molecular research center, qazvin university of medical sciences, qazvin, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

نفیسه راستگو | nafiseh rastgoo
student research committee, qazvin university of medical sciences, qazvin, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

آیدا فرجی | ayda faraji
cellular and molecular research center, qazvin university of medical sciences, qazvin, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

طاهره درگاهی | tahereh dargahi
cellular and molecular research center, qazvin university of medical sciences, qazvin, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

گیلدا خندان | gilda khandan
student research committee, qazvin university of medical sciences, qazvin, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

آروین بابایان | arvin babayan
student research committee, qazvin university of medical sciences, qazvin, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

هاشم حق دوست یزدی | hashem haghdoost yazdi
cellular and molecular research center, qazvin university of medical sciences, qazvin, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-861&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385631.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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