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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۷۴-۷۴
عنوان فارسی P ۴۳: The Role of TWIK۲ Channels on Immune Cells and its Impact in EAE/ MS Pathophysiology
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی P 43: The Role of TWIK2 Channels on Immune Cells and its Impact in EAE/ MS Pathophysiology
چکیده انگلیسی مقاله TWIK2 ion channels (K2P6.1, encoded by a gene named Kcnk6) belong to the family of two-pore domain potassium channels. TWIK2 is also considered as a "silent" channel because of its inability to produce measurable currents in heterologous expression systems and its intracellular retention. It is expressed in different mammalian tissues including lymphoid organs and the vascular system. However, the role that TWIK2 channels play in the immune system is far from being understood. Previous studies have already revealed that some other members of the K2P channel family have a crucial role in the pathogenesis of multiple sclerosis (MS), an autoinflammatory disorder of the central nervous system. We aim at unravelling the reasons of TWIK2 channels being silent and their role on immune cells in respect to the pathophysiology of MS and its animal model experimental autoimmune encephalomyelitis (EAE) which might offer a novel therapeutic target. Hereby, we have investigated the distribution of TWIK2 channels in different tissues and cells, revealing strong TWIK2-expression levels on dendritic cells, macrophages and T-lymphocytes. Future experiments will focus on the role of TWIK2 channels in vivo by inducing MOG-specific EAE in TWIK2-/- and WT animals to investigate the disease course and perform ex vivo functional assays with MOG-specific, autoreactive immune cells.
کلیدواژه‌های انگلیسی مقاله Mammalian, Immune Cells, Macrophages
نویسندگان مقاله li ming lee | li ming lee
department of neurology, clinic of neurology and institute for translational neurology, university of münster, münster, germany


juncal fernandez orth | juncal fernandez orth
department of neurology, clinic of neurology and institute for translational neurology, university of münster, münster, germany


tobias ruck | tobias ruck
department of neurology, clinic of neurology and institute for translational neurology, university of münster, münster, germany


استفان bittner | stefan bittner
department of neurology, university medical center of the johannes gutenberg-university, mainz, germany


nikole bobak | nikole bobak
labex icst, institut de pharmacologie moléculaire et cellulaire, cnrs, and université de nice sophia-antipolis, sophia-antipolis, valbonne, france


florian lesage | florian lesage
labex icst, institut de pharmacologie moléculaire et cellulaire, cnrs, and université de nice sophia-antipolis, sophia-antipolis, valbonne, france


sven meuth | sven meuth
department of neurology, clinic of neurology and institute for translational neurology, university of münster, münster, germany
نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-892&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-393347.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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