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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۹۸-۹۸
عنوان فارسی P ۶۷: The Role of Neuroinflammation in Dysfunction of Adult Hippocampal Neurogenesis
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی P 67: The Role of Neuroinflammation in Dysfunction of Adult Hippocampal Neurogenesis
چکیده انگلیسی مقاله Neuroinflammation as a protective mechanism for repairing tissue damage in the central nervous system (CNS), has been classified into two types: acute and chronic. It is characterized by the activation of microglia and astrocytes and the increase levels of different chemokines and cytokines. Neuroinflammation can be harmful, and it is a common pathological feature in neurodegenerative and psychiatric conditions. On the other word, neuroinflammation effects on important processes in the brain such as adult neurogenesis. Neurogenesis is the process by which new neurons are generated during the embryonic development of CNS and in the adult brain, and it has an important role in the repairing adult brain. Therefore, we review the effect of neuroinflammation on neurogenesis. Chronic neuroinflammation can impair to hippocampal neurogenesis in the adult brain. It has been proven that chronic neuroinflammation due to increased microglial activation and increased production of pro‐inflammatory cytokines (e.g. interleukin-1β, interleukin-6, and tumor necrosis factor-α.) has deleterious effects on neurogenesis. It has been also demonstrated that microglial activation by reducing cell proliferation and newborn cell survival leads to hippocampal neurogenesis dysfunction in the adult brain. It can be concluded that neurogenesis as a physiologic phenomenon in hippocampus affected by neuroinflammation. New studies in this field can be helped to treat related neurodegeneration disease. 
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نویسندگان مقاله فریده باغیشنی | farideh baghishani
department of anatomy and cell biology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سجاد سحاب نگاه | sajad sahab negah
a. department of neuroscience, mashhad university of medical sciences, mashhad, iran b. shefa neuroscience research center, khatam alanbia hospital, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

ندا فضایلی جوان | neda fazaeli javan
departman of biology, faculty of science, ferdowsi university of mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

احسان باغیشنی | ehsan baghishani
islamic azad university, mashhad branch, mashhad, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-917&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-393371.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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