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عنوان فارسی P ۱۴۰: Stem Cells in Multiple Sclerosis
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P 140: Stem Cells in Multiple Sclerosis
چکیده انگلیسی مقاله Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). Inflammation caused by immune cells destroy the myelin and then axon. CNS failure to complete repair results in permanent disabilities. Some types of stem cells have special potentials to repair these injuries and even cure MS. Neural crest stem cells with a mutual origin with CNS and the ability of differentiation to different types of neural cells can replace lost cells. They also increase survival and development of neurons by secreting neurotrophins. Mesenchymal stem cells have a high potential to identify affected areas and migrate to there. They reduce inflammation and autoimmune reactions by affecting on all types of immune cells. Mesenchymal stem cells change phenotypes of T cells from inflammatory form to anti-inflammatory form by decreasing of INF and increasing of IL4 production. It also increases regulatory T cells (Treg) and reduce killer T lymphocytes proliferation. And on the other hand reduce pro-inflammatory factors interaction with nerve cells by improving the blood-brain barrier performance. Also their impact on demyelination and restoration of nerve cells has been demonstrated. Olfactory ensheathing cells leads to regeneration of axons and myelin by production and secretion of growth factors and principal components of nerve cells membranes. It accelerates the healing by reorganization of glial scar, tissue support and stimulate vascularization. Hematopoietic stem cells can rebuild the immune system and completely suppress autoimmune reactions. Oligodendrocyte precursor cells regenerate myelination by differentiation to oligodendrocytes. Endothelial precursor cells suppress inflammation. Conclusion: Stem cells have significant potential to treat MS with various mechanisms. Knowing the features of these cells and their effect mechanisms are very important to find an effective treatment for MS.
کلیدواژه‌های انگلیسی مقاله Multiple sclerosis, Stem cell, Neuroinflammation
نویسندگان مقاله آیدا جوادزاده | aida javadzadeh
islamic azad university, mashhad branch, mashhad, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

محمدرضا خجسته | mohammad reza khojaste
islamic azad university, mashhad branch, mashhad, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

علی شریعت رضوی | ali shariat razavi
islamic azad university, mashhad branch, mashhad, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

سجاد سحاب نگاه | sajad sahab negah
a. department of neuroscience, mashhad university of medical sciences, mashhad, iran b. shefa neuroscience research center, khatam alanbia hospital, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-991&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-393444.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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