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Iranian Journal of Veterinary Science and Technology، جلد ۷، شماره ۲، صفحات ۲۸-۰
عنوان فارسی ﺑﺮرﺳﯽ اﺛﺮات درﻣﺎﻧﯽ ﺗﻮﻟﺘﺮوﻣﺎیﺴﯿﻦ ﺑﺮ درﻣﺎن ﭘﻮﻧﻮﻣﻮﻧﯽ ﻧﺸﺨﻮارﮐﻨﻨﺪﮔﺎن ﮐﻮﭼﮏ
چکیده فارسی مقاله ﻫﺪف از اﻧﺠﺎم ایﻦ ﻣﻄﺎﻟﻌﻪ ارزیﺎﺑﯽ ﺑﺎﻟﯿﻨﯽ ,ﺧﻮن ﺷﻨﺎﺳﯽ، ﻣﯿﮑﺮوب ﺷﻨﺎﺳﯽ و اﺛﺮات آﺳﯿﺐ ﺷﻨﺎﺳﯽ ﻣﯿﮑﺮو و ﻣﺎﮐﺮو داروی ﺗﻮﻟﺘﺮوﻣﺎیﺴﯿﻦ ﺑـﺮ ﭘﻨﻮﻣـﻮﻧﯽ ﺑـﺰ ﺑـﺎ ﻧﺸـﺎﻧﻪ ﻫـﺎی 9 ﮔﻮﺳـﻔﻨﺪ و 10 ﻋﻔﻮﻧﯽ ﻧﺸﺨﻮارﮐﻨﻨﺪﮔﺎن ﮐﻮﭼﮏ و ﻫﻤﭽﻨﯿﻦ ﻋﻮارض ﺳﻮء ﻧﺎﺷﯽ از دارو در ﻣﺤﻞ ﺗﺰریﻖ اﺳﺖ .ﺑـﻪ ﻫﻤـﯿﻦ ﻣﻨﻈـﻮر ﭘ اره داﻣﭙﺰﺷﮑﯽ ﺧﺮاﺳﺎن رﺿﻮی ﺟﻤﻊ آوری ﺷﺪﻧﺪ ﮐﻪ ﺗﻤﺎﻣﯽ آﻧﻬﺎ ﻋﺎری از اﻧﮕﻞ ﻫﺎی داﺧﻠﯽ و ﮐﯿﺴﺖ ﻫﯿﺪاﺗﯿﺪ ریﻮی ﺑﻮدﻧ ﻨﻮﻣﻮﻧﯽ در ﻣﺮﮐﺰ ﺗﺤﻘﯿﻘﺎت اد ﺪ . ﺑـﻪ mg/kg2,5 ﺳﻮاپ ﺑﯿﻨﯽ ﺣﻠﻘﯽ ﺑﺮای ﮐﺸﺖ ﭘﺎﺳﺘﻮرﻻ و ﻣﺎیﮑﻮﭘﻼﺳﻤﺎ و ﻧﻤﻮﻧﻪ ﺧﻮن ﺑﺮای آزﻣﺎیﺸﺎت ﺧﻮن ﺷﻨﺎﺳﯽ ﮔﺮﻓﺘﻪ ﺷـ ﺪ.ﺗﻮﺗﻠﺮوﻣﺎیﺴـﯿﻦ ﺑـﺎ دور ﭘﺲ از ﺗﺰریﻖ درﺟﻪ ﺣﺮارت،ﺗﻌﺪاد ﺗﻨﻔﺲ ، ﺿﺮﺑﺎن ﻗﻠﺐ و ﺗﻌﺪاد ﺣﺮﮐﺎت ﺷـﮑﻤﺒﻪ، ﺻـﺪای 72 و 24،48ﺻﻮرت زیﺮﺟﻠﺪی ﺗﺰریﻖ ﺷﺪ و در ﺳﺎﻋﺘﻬﺎی ﺻﻔﺮ، ﺳﻮاپ ﺑﯿﻨﯽ ﺗﮑﺮار ﺷـ ﺪ.ﻻزم ﺑـﻪ ذﮐـﺮ 3 ﻧﻤﻮﻧﻪ ﮔﯿﺮی ﺧﻮن و روز 3 و 1 ﺻﺒﺢ ﺛﺒﺖ ﮔﺮدیﺪ .در روزﻫﺎی 12 ﺗﺎ 9ریﻪ و ﻧﻮع ﺗﺮﺷﺤﺎت ﺑﯿﻨﯽ در ﺑﯿﻦ ﺳﺎﻋﺎت ﭘﺲ از ﺗﺰریﻖ ذﺑﺢ ﺷﺪﻧﺪ ﺑﺎزرﺳﯽ ﭘﺲ از ﮐﺸﺘﺎر ﺑﺮ روی ﺑﺎﻓـﺖ ریـﻪ ﺻـﻮرت ﮔﺮﻓـﺖ و از ﻣـﻮارد ﺑـﺎ 15 و ﺑﻘﯿﻪ در روز 9 ﮔﻮﺳﻔﻨﺪ و ﺑﺰ در روز 2 اﺳﺖ ﮐﻪ ﺟﺮاﺣﺖ ریﻮی یﮏ ﻧﻤﻮﻧﻪ ﺑﺎﻓﺘﯽ ﺑﺮای آﺳﯿﺐ ﺷﻨﺎﺳﯽ ﮔﺮﻓﺘﻪ ﺷﺪ. ﭘـﺲ از ﺗﺰریـﻖ 72و 24،48 (اﺧﺘﻼف ﻣﻌﻨﯽ داری ﺑﯿﻦ درﺟﻪ ﺣﺮارت ﺑﺪن، ﺿﺮﺑﺎن ﻗﻠﺒﻮ ﺗﻌﺪاد ﺗﻨﻔﺲ در زﻣﺎﻧﻬﺎی ﺻـﻔﺮ ، 1 :ﻧﺘﺎیﺞ ﺣﺎﮐﯽ از ایﻦ ﺑﻮد ﮐﻪ ﭘـﺲ از ﺗﺰریـﻖ 72و 24،48 (اﺧﺘﻼف آﻣﺎری ﻣﻌﻨﯽ داری ﺑﯿﻦ ﺗﻌﺪاد ﮔﻮیﭽﻪ ﻫﺎی ﺳﻔﯿﺪ و ﺗﻌﺪاد ﻧﻮﺗﺮوﻓﯿﻞ ﻫﺎ در زﻣﺎﻧﻬﺎی ﺻﻔﺮ،2.ﺗﻮﻟﺘﺮوﻣﺎیﺴﯿﻦ وﺟﻮد دارد ﻣـﻮرد ایـﻦ ﺑـﺎﮐﺘﺮی از 2 (در ﺗﻤﺎﻣﯽ ﻧﻤﻮﻧﻪ ﻫﺎ ی ﺑﯿﻨﯽ ﭘﺎﺳﺘﻮرﻻ ﺟﺪا ﺷﺪ اﻣﺎ ﭘﺲ از ﺗﺰریﻖ ﺗﻮﻟﺘﺮوﻣﺎیﺴﯿﻦ ﺗﻨﻬـﺎ در 3. ﺗﻮﻟﺘﺮوﻣﺎیﺴﯿﻦ وﺟﻮد دارد.وﺟﻮد دارد (ﺟﺮاﺣﺎت ریﻮی ﻣﺸﺎﻫﺪه ﺷﺪه در ﻧﯿﻤﯽ از ﮔﻮﺳﻔﻨﺪان و 5. %ﻣﻮارد ﻗﺒﻞ و ﺑﻌﺪ از ﺗﺰریﻖ ﺗﻮﻟﺘﺮوﻣﺎیﺴﯿﻦ ﻣﺎیﮑﻮﭘﻼﺳﻤﺎ ﮐﺸﺖ ﺷﺪ 57,9 (در 4.ﺳﻮاپ ﮐﺸﺖ ﺷﺪ . %ﺑﺰﻫﺎ ﺷﺎﻣﻞ ﺗﺮاﮐﻢ ﻟﻮب آﭘﯿﮑﺎل، ﺟﺴﺒﻨﺪﮔﯽ ﺑﺮوﻧﮑﻮﭘﻨﻮﻣﻮﻧﯽ و ﭘﻠﻮرزی ﺑﻮد 44 ﻧﺘﺎیﺞ ایﻦ ﻃﺮح ﻧﺸﺎن ﻣﯽ دﻫﺪ ﮐﻪ داروی ﺗﻮﻟﺘﺮوﻣﺎیﺴﯿﻦ ﻫﯿﭽﮕﻮﻧﻪ اﺛﺮ ﺿﺪ ﻣﯿﮑﺮوﺑﯽ ﺑﺮ روی ﻣﺎیﮑﻮﭘﻼﺳﻤﺎ ﻧﺪارد.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A survey on the efficacy of tulathromycin in the treatment of infectious pneumonia of small ruminants in Iran
چکیده انگلیسی مقاله The principle aims of this study were to evaluate clinical, hematological, microbiological and macro and micro pathological effects of tulathromycin on small ruminants infectious pneumonia (IP) and to determine the side effects of the drug in the injected site. For this purpose, all ruminants (10 sheep and 9 goats) with signs of IP were assembled in the Khorasan-E-Razavi Province Veterinary Organization research centre. Also, all of these animals were free of internal parasite infestations and free of hydrated cysts in the lung tissue. Before tularthromycin injection, samples were taken as nasopharyngeal swabs for culturing Pasteurella spp. and Mycoplasma spp. and performing the Cell Blood Count (CBC) for blood. Each animal was injected at the dose of 2.5 mg/Kg subcutaneously. In 24-, 48- and 72-hours after injection, body temperature (BT), respiratory rate (RR), heart rate (HR), ruminal contraction rate (RCR), lung sounds (LS) and nasal discharges (ND) were recorded between 9-12 pm. Meanwhile on day 1 and day 3, the blood sampling was repeated and on day 3 nasopharyngeal swabs were repeated. Furthermore, 9 sheep and goats were killed on day 9 and the remainders were killed on the day 15 following injection and post-mortem inspections were conducted on lungs. From cases with lung lesions, a sample was taken for histopathological examination. The data showed that: A) The mean difference of BT, RR and HR of 0-, 24-, 48-, and 72-hrs after Tulathromycin injection was significantly different (p< 0.05). B) The mean difference of No. WBC and % neutrophils of 0-, 24-, 48-, 72-hrs was significant (p< 0.05). C) Pasteurella spp. was isolated from all sheep and goats before injection while this organism was cultured in only 2 of the animals on day 3 after tulathromycin injection (p< 0.05). D) Mycoplasma spp. was cultured from 57.9% of the small ruminants and the results were identical in the second culturing with the exception of one animal. Mycoplasma spp. was cultured from 57.9% of the small ruminants and the results were identical in the second culturing with the exception of one animal. E) 50% and 44.4% of the sheep and goats that were killed on the 9th and 15th days post-injection showed various pulmonary lesions including apical lob consolidation, apical lob consolidation plus adhesion, bronchopneumonia plus observed pleurisy. On the basis of this investigation Tulathromycin has not had any antibacterial effect on Mycoplasma spp.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله امیر مقدم جعفری | amir moghaddam jafari


تقی ویدا | taghi taghipour bazargani


حسن اسدزاده هروی | hasan assadzadeh heravi


مهین ترابی | mahin torabi


نشانی اینترنتی http://ijvst.um.ac.ir/index.php/veterinary/article/view/16982
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/468/article-468-393503.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
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