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Iranian Journal of Veterinary Science and Technology، جلد ۵، شماره ۲، صفحات ۱-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of cobalt nano-particles on serum biochemical and histopathological changes in liver and kidney of lambs
چکیده انگلیسی مقاله Cobalt is an essential co-factor in red blood cell production and function and its deficiency may produce clinical signs in sheep. Thus, present study was designed to evaluate the effect of cobalt nano-particles on serum biochemical factors and histopathological changes in liver and kidnies of lambs. Study was carried out in 3 groups of lambs (4 lambs per group). One group of lambs was kept as control group. Second and third group respectively received cobalt nano-particles and conventional cobalt chloride suspension daily for a period 25 day. Blood sample and then serum was collected before and at the end of study. Activity of ALT,AST, ALP and level of BUN, creatinine and vitamin B12 were measured in serum of lambs. Tissue sections of liver and kidney were stained with hematoxylin and eosin and examined by light microscopy. Activity of ALT, BUN and vitamin B12 was significantly increased by cobalt nano-particles and conventional cobalt chloride. Fatty change of hepatocytes occured by conventional cobalt and granulomatous hepatitis, focal necrosis of hepatocytes and degeneration of hepatocytes by the nano cobalt was identified in liver. There were not any significant lesions and alteration in the kidnies of treated groups. Thus, cobalt nano-particles have similar effect to conventional cobalt for using in sheep with cobalt deficiency.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سید مرتضی قریشی | seyed morteza ghoreishi


حسین نجف زاده | hossein najafzadeh


بابک محمدیان | babak mohammadian


عیسی رحیمی | eisa rahimi


محمدرضا افضل زاده | mohammad reza afzalzadeh


محمد کاظمی ورنامخواستی | mohammad kazemi varnamkhasti


گنجعلی دارانی | ganjeali darani


نشانی اینترنتی http://ijvst.um.ac.ir/index.php/veterinary/article/view/16589
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/468/article-468-393533.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
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