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Iranian Journal of Veterinary Science and Technology، جلد ۳، شماره ۱، صفحات ۱۱-۰
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عنوان انگلیسی Clinical and pathological study of experimentally- induced yew (Taxus baccata) poisoning in sheep
چکیده انگلیسی مقاله Acute yew (Taxus baccata) intoxication was induced in 7 adult sheep by oral administration of the plant materials at the dose of 2.5g/kg body weight. Blood samples for hematology and serum biochemistry were collected before and after the induced intoxication.Electrocardiography was performed using a base-apex lead. Intoxicated animals displayed lethargy, depression, bradycardia and varying intensity of heart sounds. The ECGs of intoxicated sheep showed a variety of arrhythmias and abnormalities including multifocal ventricular tachycardia, idioventricular and idiojunctinal rhythm and QRS and T widening. Four sheep died within 4-16 hours after yew administration. Significant increase of white blood cells, total neutrophil counts and serum sodium concentration were observed. Post mortem examination and histological evaluation were done with special regards on tissue changes of the myocardium and conduction system. There were hyperemia, focal hemorrhage and multifocal nonsuppurative interstitial myocarditis with mild focal cardiac muscle cell degeneration and necrosis in the affected hearts which appeared more prominent in the right atrium. Histopathological examination of cardiac conduction system also revealed moderate to severe interstitial edema with inflammation of the SA-node, AV-node, the bundle branches and His-bundle in all cases which was most severe in the AV-node and the His-bundle. Oral administration of dried leaves of T. baccata, at the dose of 2.5g/kg can induce acute toxicity, manifested clinically by a variety of cardiac arrhythmia and myocardial lesions including special conduction system in pathology.
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نویسندگان مقاله محمدرضا اصلانی | mohammad reza aslani


علیرضا تقوی | alireza taghavi razavizadeh


احمدرضا موثقی | ahmad reza movassaghi


مهرداد مهری | mehrdad mohri


ابوالقاسم نبی پور | abolghassem nabipour


علی رضاخانی | ali rezakhani


سمانه یعقوبی فضل | samaneh yaghoobi faz


علی عندلیب مقدم | ali andalib moghadam


فاطمه احمدی | fatemeh ahmadi


نشانی اینترنتی http://ijvst.um.ac.ir/index.php/veterinary/article/view/11876
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/468/article-468-393574.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
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