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Iranian Journal of Chemistry and Chemical Engineering، جلد ۳۶، شماره ۱، صفحات ۱۱۷-۱۲۴
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عنوان انگلیسی A Quick and Sensitive Liquid Chromatography-Tandem Mass Spectrometry (LC-MS) Method for the Evaluation of Two Formulations of Amlodipine and Atorvastatin in Healthy Male Volunteers
چکیده انگلیسی مقاله An open-label, single-dose, randomized, 2-way crossover study was conducted in fasted healthy Iranian male volunteers. Eligible participants randomly assigned in a 1:1 ratio to be given one tablet of the test or reference formulation, followed by a 2-week washout period and administration of the exchange formulation. A quick and susceptible Liquid Chromatography–tandem Mass Spectrometry (LC-MS) method for the evaluation of amlodipine and atorvastatin in tablets.Revealing of analysts was achieved by tandem mass spectrometry with ElectroSpray Ionization (ESI) interface in positive ion mode was operated under the multiple-reaction monitoring mode. The assay results ascertain the presence and compendia quality of amlodipine and atorvastatin in all these products. The validation tests on the developed method indicated an acceptable degree of linearity, sensitivity, precision, accuracy and recovery for the method. The intra-day and inter-day precision and accuracy results were well within the acceptable limits. The method is rapid, simple, very stable and specific for the partition, assignment, evaluation of amlodipine and atorvastatin healthy Iranian adult male volunteers.
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نویسندگان مقاله حسین دانافر |
department of pharmaceutics, school of pharmacy, zanjan university of medical sciences, postal code 45139-56184, zanjan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

مهرداد حمیدی |
department of pharmaceutics, school of pharmacy, zanjan university of medical sciences, zanjan, i.r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

نشانی اینترنتی http://www.ijcce.ac.ir/article_25196_8046ea07e78743f6a3d88794c1dfccea.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/444/article-444-394144.pdf
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زبان مقاله منتشر شده en
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