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Iranian Journal of Chemical Engineering، جلد ۱۴، شماره ۱، صفحات ۳-۱۴
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عنوان انگلیسی Production and Characterization of Gelatine Based Electro-spun Nano-fibres as Burn Wound Dressings
چکیده انگلیسی مقاله Silver sulfadiazine is used to prevent and treat infections of second- and third-degree burns. It kills a wide variety of bacteria. In this study silver sulfadiazine was used in gelatin based electro-spun nano-fibers with various drug to polymer ratios (0, 5, 10, 15 and 20 %). SEM, EDX and FTIR analysis showed that the continuous, bead-free, fine fibers containing silver sulfadiazine as an antibiotic drug were successfully produced. The release profiles of the loaded drug from the produced nano-fibrous dressings were evaluated by an in vitro elution method. It was observed that the sample with 10wt% of gelatin has had the optimum trend of release. Moreover, antibacterial activity of the dressings was evaluated against the pathogenic micro-organisms S.aureus and E.coli in the nutrient agar solid medium. It was obvious that all the samples had antibacterial activity against these two bacteria. The produced silver sulfadiazine loaded gelatin based electro-spun nano-fibrous dressings have the potential for being used in the wound healing applications.
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نویسندگان مقاله یاسمن همدانی |
department of polymer engineering, science and research branch, islamic azad university, p.o.box 14155 4933, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نغمه فاضلی |
department of polymer engineering, science and research branch, islamic azad university, p.o.box 14155 4933, tehran, iran.
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

جلال برزین |
iran polymer and petrochemical institute, p.o. box 14965 115, tehran, iran

نشانی اینترنتی http://www.ijche.com/article_43879_10b2517b40a68de359c15cb59cd78bc4.pdf
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