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Journal of Arthropod-Borne Diseases، جلد ۹، شماره ۱، صفحات ۷۱-۸۳
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عنوان انگلیسی Resistance Mechanisms of Anopheles stephensi (Diptera: Culicidae) to Temephos
چکیده انگلیسی مقاله Background : Anopheles stephensi is a sub-tropical species and has been considered as one of the most important vector of human malaria throughout the Middle East and South Asian region including the malarious areas of southern Iran. Current reports confirmed An. stephensi resistance to temephos in Oman and India. However, there is no comprehensive research on mechanisms of temephos resistance in An. stephensi in the literature. This study was designed in order to clarify the enzymatic and molecular mechanisms of temephos resistance in this species. Methods : Profile activities of α- and ß-esterases, mixed function oxidase (MFO), glutathione-S-transferase (GST), insensitive acetylcholinesterase, and para-nitrophenyl acetate (PNPA)-esterase enzymes were tested for An. stephensi strain with resistance ratio of 15.82 to temephos in comparison with susceptible strain. Results : Results showed that the mean activity of α-EST, GST and AChE enzymes were classified as altered indicating metabolic mechanisms have considerable role in resistance of An. stephensi to temephos. Molecular study using PCR-RFLP method to trace the G119S mutation in ACE-1 gene showed lack of the mutation responsible for organophosphate insecticide resistance in the temephos-selected strain of An. stephensi. Conclusion : This study showed that the altered enzymes but not targets site insensitivity of ACE-1 are responsible for temephos resistance in An. stephensi in south of Iran.
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نویسندگان مقاله ابوذر سلطانی | aboozar soltani
department of medical entomology and vector control, school of health, shiraz university of medical sciences, shiraz, iran and department of medical entomology and vector control, school of public health and national institute of health research, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

حسن وطن دوست | hassan vatandoost
department of medical entomology and vector control, school of public health and national institute of health research, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدعلی عشاقی | mohammadali oshaghi
department of medical entomology and vector control, school of public health and national institute of health research, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ناصح ملکی رواسان | naseh maleki ravasan
department of medical entomology and vector control, school of public health and national institute of health research, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احمدعلی عنایتی | ahmadali enayati
school of public health and health research centre, mazandaran university of medical sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

فاطمه عسگریان | fatemeh asgarian
school of public health and health research centre, mazandaran university of medical sciences, sari, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

نشانی اینترنتی http://jad.tums.ac.ir/index.php/jad/article/view/119
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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