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Iranian Journal of Public Health، جلد ۴۶، شماره ۵، صفحات ۶۱۲-۶۱۹
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عنوان انگلیسی Application of Fuzzy Logic in Oral Cancer Risk Assessment
چکیده انگلیسی مقاله Background: The mapping of the malignization mechanism is still incomplete, but oxidative stress is strongly correlated to carcinogenesis. In our research, using fuzzy logic, we aimed to estimate the oxidative stress related-cancerization risk of the oral potentially malignant disorders. Methods: Serum from 16 patients diagnosed (clinical and histopathological) with oral potentially malignant disorders (Dept. of Cranio-Maxillofacial Surgery and Radiology, ”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj Napoca, Romania) was processed fluorometric for malondialdehyde and proton donors assays (Dept. of Physiology,”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania). The values were used as inputs, they were associated linguistic terms using MIN-MAX method and 25 IF-THEN inference rules were generated to estimate the output value, the cancerization risk appreciated on a scale from 1 to 10 - IF malondialdehyde is very high and donors protons are very low THEN the cancer risk is reaching the maximum value (Dept. of Industrial Engineering, Faculty of Managerial and Technological Engineering, University of Oradea, Oradea, Romania) (2012-2014). Results: We estimated the cancerization risk of the oral potentially malignant disorders by implementing the multi-criteria decision support system based on serum malondialdehyde and proton donors' values. The risk was estimated as a concrete numerical value on a scale from 1 to 10 depending on the input numerical/linguistic value. Conclusion: The multi-criteria decision support system proposed by us, integrated into a more complex computerized decision support system, could be used as an important aid in oral cancer screening and establish future medical decision in oral potentially malignant disorders.
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نویسندگان مقاله ioana scrobotă | ioana scrobotă


grigore băciuț | grigore băciuț


adriana gabriela فیلیپ | adriana gabriela filip


bianca todor | bianca todor


florin blaga | florin blaga


mihaela felicia băciuț | mihaela felicia băciuț


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/9909
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-398183.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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