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Journal of Arthropod-Borne Diseases، جلد ۳، شماره ۲، صفحات ۷-۱۱
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عنوان انگلیسی Evaluation of Serum Levels of Zinc, Copper, Iron, and Zinc/Copper Ratio in Cutaneous Leishmaniasis
چکیده انگلیسی مقاله Background: The purpose of this study was to evaluate the levels of zinc (Zn), copper (Cu), iron (Fe) and zinc/ cop­per ratio in the serum of patients with cutaneous leishmaniasis in Qom Province, center of Iran. Methods: Serum levels of zinc and copper were determined by flame atomic absorption spectrophotometer and serum iron concentration was measured by using an Auto Analyzer. The study group consisted of 60 patients with cutaneous leishmaniasis and the control group of 100 healthy volunteers from the same area who were not exposed to cutane­ous leishmaniasis. Result: There were no statistically significant differences in age and body mass index between the two groups. Se­rum Zn ( P < 0.001) and Fe ( P < 0.05) levels were lower in patients with cutaneous leishmaniasis than the control group. We also found serum Cu concentration ( P < 0.05) in the patient group was significantly higher than that of the control group. However, zinc/ copper ratio ( P < 0.001) was lower in patients with cutaneous leishmaniasis than in the control group. Conclusion: Our data indicated that Zn/Cu ratio was significantly lower in patients with CL as compared to the con­trols. Earlier reports suggest that, this ratio imbalance could be a useful marker for immune dysfunction in leishma­niasis. There was also strong association of Zn, Cu and Fe with CL. It suggests the use of blood zinc, copper, iron concentration and the copper/zinc ratio (Zn/Cu), as a means for estimating the prognosis of CL.
کلیدواژه‌های انگلیسی مقاله Cutaneous leishmaniasis, Zn, Cu, Fe. Zn/Cu ratio, Iran
نویسندگان مقاله f پورفلاح | f pourfallah
department of biochemistry, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

s جوادیان | s javadian
department of biochemistry, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

زمانی | z zamani
department of biochemistry, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

r صغیری | r saghiri
department of biochemistry, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

ساسان | s sadeghi
department of biochemistry, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

b زارع | b zarea
qom central hospital, qom, iran


sh فیاض | sh faiaz
department of biochemistry, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

f میرخانی | f mirkhani
department of biochemistry, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

n فاطمی | n fatemi
department of biochemistry, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

نشانی اینترنتی http://jad.tums.ac.ir/index.php/jad/article/view/49
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