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Iranian Biomedical Journal، جلد ۲۱، شماره ۴، صفحات ۲۴۹-۲۶۰
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عنوان انگلیسی Plackett-Burman Design and Response Surface Optimization of Medium Trace Nutrients for Glycolipopeptide Biosurfactant Production
چکیده انگلیسی مقاله Background: A glycolipopeptide biosurfactant produced by Pseudomonas aeruginosa strain IKW1 reduced the surface tension of fermentation broth from 71.31 to 24.62 dynes/cm at a critical micelle concentration of 20.80 mg/L. The compound proved suitable for applications in emulsion stabilization in food, as well as in cosmetic and pharmaceutical formulations. Methods: In the present study, Plackett-Burman design (PBD) and response surface method (RSM) were employed to screen and optimize concentrations of trace nutrients in the fermentation medium, to increase surfactant yield. Results: The PBD selected 5 out of the 12 screened significant trace nutrients. The RSM, on the other hand, resulted in the production of 84.44 g glycolipopeptide/L in the optimized medium containing 1.25 mg/L nickel, 0.125 mg/L zinc, 0.075 mg/L iron, 0.0104 mg/L boron, and 0.025 mg/L copper. Conclusion: Significant second-order quadratic models for biomass (P< 0.05; adjusted R2=94.29%) and biosurfactant (R2=99.44%) responses suggest excellent goodness-of-fit of the models. However, their respective non-significant lack-of-fit (Biomass: F=1.28; P=0.418; Biosurfactant: F=1.20; P=0.446) test results indicate their adequacy to explain data variations in the experimental region. The glycolipopeptide is recommended for the formulation of inexpensive pharmaceutical products that require surface-active compounds
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نویسندگان مقاله maurice ژورژ ekpenyong | maurice george ekpenyong
environmental microbiology and biotechnology unit, department of microbiology, faculty of biological sciences, university of calabar, p.m.b.1115 calabar, nigeria


sylvester پیتر antai | sylvester peter antai
environmental microbiology and biotechnology unit, department of microbiology, faculty of biological sciences, university of calabar, p.m.b.1115 calabar, nigeria


atim دیوید asitok | atim david asitok
environmental microbiology and biotechnology unit, department of microbiology, faculty of biological sciences, university of calabar, p.m.b.1115 calabar, nigeria


bassey offiong ekpo | bassey offiong ekpo
exploration, research and services section, research and development r amp;amp;d division, nigerian national petroleum corporation nnpc , port-harcourt, nigeria
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-656&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-399412.pdf
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Related Fields
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